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Strain
B6.Cg-Ryr1tm2.1Alle/+

Summary Data Summary
Official Name B6.Cg-Ryr1tm2.1Alle/+
Common Name RyR1-R163C
Description Four nucleotides in exon 6 were modified (CgAgttggGgaT to
TgCgttggAgaC) to encode an Arginine to Cysteine change of
codon 163 as well as to generate a new BsmBI restriction
site. In addition, a floxed neomycin cytosine deaminase
cassette was inserted in the EagI site in intron 6. Germline
deletion of the selection cassette was subsequently
accomplished in the germ line by breeding to
Alp1tm1(cre)Nagy mice.
Development Status Phenotyping ongoing
Creation Method knockin
Breeding Type backcross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 10


Investigators
NameInstitution
Isaac PessahUniversity of California - Davis


Genomic Information
GeneAllele 1Allele 2Protocol
Ryr1knockinwildNot Specified


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