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Tracers in Metabolic Research
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Four nucleotides in exon 6 were modified (CgAgttggGgaT to
TgCgttggAgaC) to encode an Arginine to Cysteine change of
codon 163 as well as to generate a new BsmBI restriction
site. In addition, a floxed neomycin cytosine deaminase
cassette was inserted in the EagI site in intron 6. Germline
deletion of the selection cassette was subsequently
accomplished in the germ line by breeding to
Genomics - Modifications
University of California - Davis
Curation Flag Information
New comment to be added:
Analysis of energy expenditure and core temperature during temperature challenge in a model of malignant hyperthermia
Assessment of RyR1 mutant mouse activity
Effect of Ryr on running bouts
Effects of Ryanadine receptor hemizygosity on energy expenditure with running wheel
Energy expenditure in WT and RyR1 R163C mice during acute heat stress
Examine effect of Ryr1 mutation on energy expenditure in temperature-challenged male and female mice (2nd cohorts)
Examine effect of Ryr1 mutation on energy expenditure in temperature-challenged male mice (male cohort1)
Measurement of energy expenditure at different temperatures in WT and RyR1-R163C heterozygotes (thermoneutral zone testing)
Measurement of standard energy expenditure at 22C in Control and RyR1-R163C Heterozygotes
Measurement of standard energy expenditure at 22C in Control and RyR1-R163C Heterozygotes (female cohorts 2 &3, male cohort2)
Measurement of standard energy expenditure at 22C in Control and RyR1-R163C Heterozygotes (MALES-cohort1)
Temperature by telemetry during CLAMS analysis
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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