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Experiment

Temperature by telemetry during CLAMS analysis
Summary Data Summary
Investigator Rutkowsky, Jennifer
Description Mutations in either type 1 ryanodine receptor (RyR1) cause malignant
hyperthermia susceptibility (MHS) in humans and animals. Temperature telemeters
are implanted in MHS mice and the influence of ambient temperature eon core body
temperature is measure. The proposed studies are transformative because they
will lead to a better understanding how MHS mutations produce phenotypic
differences in clinical MH and progressive muscle damage.
For this pilot study,four transgenic mice will have telemeters implanted and
core body temperature monitored during a temperature challenge where ambient
temperature is raised from 12 to 32 C. This is linked to order # 13174
Status Completed
Public Release 11/20/2016
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagNo Experimental GroupExperiment DescriptionNeed Conditions
Data Analysis
TypeCount
Animals4
Experimental Conditions3
Catalog Items1
Curation Info (# flags)3
Phenotype Assays1
Phenotype Measurements64812
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
RyR1-R163C
4
0
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Time Sample Taken (sec)

 time sample taken
Time in seconds a sample was taken


Phenotype Assays Add / Edit


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