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Experiment

Effect of Ryr on running bouts
Summary Data Summary
Investigator Pessah, Isaac
Description Mutations in Either type 1 receptor (RyR1) or the dihydropyridine
receptorsubunit Cav1.1 cause malignant hyperthermia susceptiblity (MHS) in
humans and animals. It is necessary to understand how altered RyR1 channel
regulation influences baal changes in mitochondrial bioenergetics, produces
oxidative stress and promotes progressive muscle change.

Applicable research area(s): Metabolism
Status Completed
Public Release 8/15/2019
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals30
Experimental Conditions3
Catalog Items1
Curation Info (# flags)0
Phenotype Assays3
Phenotype Measurements450
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
8
8
0
RyR1-R163C
6
8
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Light-Dark Period

 Dark
The Dark period
 Light
The light period



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