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Experiment

The investigation of loss of Sec63 and Xbp1 in collecting duct. March 15.
Summary Data Summary
Investigator Ishikawa, Yasunobu
Description SEC63 is one of genes linked with the occurrence of autosomal dominant
polycystic liver disease. The product of SEC63, SEC63p is a protein associated
with the SEC61 translocon and involved in co-translational protein translocation
and folding. In the presence of endoplasmic reticulum stress, a housekeeping
mechanism called the unfolded protein response (UPR) is turned on in order to
mitigate stress. The UPR is mediated by three major stress sensors, IRE1a, PERK
and ATF6. Phosphorylation of IRE1a leads to spliced XBP1 which is a
transcription factor that activates transcription of chaperones and proteins
involved in ER-associated degradation. In the current study we investigated the
effect of Xbp1 inactivation in the kidney in the presence and absence of Sec63.
Status Completed
Public Release 6/21/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainMetadata
Data Analysis
TypeCount
Animals24
Experimental Conditions1
Catalog Items2
Curation Info (# flags)2
Phenotype Assays2
Phenotype Measurements47
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
Sec63 Xbp1 DKO
7
12
0
Xbp1 KO
2
3
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Experimental Group
Experimental Factor Values


Phenotype Assays Add / Edit


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