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Experiment

Hyperinsulinemic clamp Order #19673, 11/10/2015

Summary

Data Summary

Investigator	Sirvent, Pascal
Description	Mice homozygous for the diabetes spontaneous mutation (Leprdb) become obese at approximately three to four weeks of age. Elevations of plasma insulin begin at 10 to 14 days and elevations of blood sugar at four to eight weeks. Homozygous mutant mice are polyphagic, polydipsic, and polyuric. Applicable research area(s): Diabetes, Obesity, Metabolism
Status	Completed
Public Release	6/22/2018
Animal Age	Measured In: week(s) post-natal (w)
Flags

Data Analysis

DOWNLOAD ALL DATA (.csv)

Type	Count
Animals	23
Experimental Conditions	5
Catalog Items	4
Curation Info (# flags)	2
Phenotype Assays	18
Phenotype Measurements	6509
Histology Images	0
Publications	0

Animals

Strain Name	Common Name	Females	Males	Unknown
C57BL/6	C57BL/6	0	11	0
BKS(D)-Lepr^db/JOrlRj	C57BLKS/J ^db/db	0	12	0

Animals/Strains

Experimental Factors

	Categorical Values
	Name / Abbreviation	Description
	Experimental Factor: Experimental Group
	Control	This animal belongs to the control group for the experiment.
	Experiment	This animal belongs to experimental group that is homozygous for gene manipulations.
	Experimental Factor: Mouse Diet
	Research Diets - D12451	Research Diets - D12451 Rodent Diet with 45% kcal% fat

Experimental Factor (Units)
Experimental Group
Glucose Infusion Rate (mg/kg/min) (mg/kg/min)
Insulin Infusion Rate - milliUnits (mU/kg/min)
Mouse Diet
Time Sample Taken (min)

Experimental Factor Values

Phenotype Assays Add / Edit

Name	Abbreviation
glucose, blood	blood glucose
body mass	W rodent
hematocrit, arterial	hematocrit, arterial
glucose rate of appearance, endogenous	endo RA
glucose, rate of disappearance	Rd
Kg, vastus lateralis	Kg, vastus lateralis
Rg, brain	Rg, brain
Rg, gastrocnemeous	Rg, gastrocnemeous
Rg, heart	Rg, heart
Rg, soleus	Rg, soleus
Rg, vastus lateralis	Rg, vastus lateralis
Kg, adipose	Kg, adipose
Rg, adipose	Rg, adipose
Kg, brain	Kg, brain
Kg, gastrocnemius	Kg, gastrocnemius
Kg, heart	Kg, heart
Kg, soleus	Kg, soleus
insulin, plasma, arterial	insulin, plasma, arterial

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