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Experiment

Indirect calorimetry / energy expenditure in the Promethion Order #2316
Summary Data Summary
Investigator Penner, Niki
Description Pulmonary Arterial Hypertension associated with Blood Glucose Abnormalities,
Lipid Distribution/Trafficking, Intracellular Trafficking, and Obesity
Status Completed
Public Release 7/1/2018
Animal Age Measured In: week(s) post-natal (w)
Flags
Data Analysis
TypeCount
Animals0
Experimental Conditions5
Catalog Items2
Curation Info (# flags)0
Phenotype Assays14
Phenotype Measurements0
Histology Images0
Publications0
Documents1

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Tesaglitazar
Tesaglitazar
 No Drug/Treatment
No Drug or Treatment done on these samples
 LPS
Lipopolysaccharide - induces bacterial infection
 Saline
Saline
 PEGPH20
Human Recombinant Hyduronidase P.H. 20 Drug Dose is in mg/kg body weight
 Vehicle-HN
10 mM Histidine, 130 mM NaCL at P.H. 6.5
 REGN379
REGN379 - Proprietary drug formulation
 REGN379(aDll4)
REGN379(aDll4) - Proprietary drug formulation
 Leptin
Leptin administered
 Water with 7,8 Dihydrofolate
Water with 7,8 Dihydrofolate
 Leptin/7,8 Dihydrofolate
Animal had both Leptin and Water with 7,8 Dihydrofolate.
 CD4 AT Cells
Adoptive Transfer of CD4 T cells by Tail Vein Injections.
 CD8 AT Cells
Adoptive transfer of CD8 T cells by Tail Vein Injections.
 NAPEs
N-acyl phosphatidylethanolamines (NAPEs).
 pNAPES
Cloned Arabidopsis thaliana NAPE synthase (pNAPES).
 EcN
E. coli Nissle 1917 (EcN).
 pEcN
pEcN is EcN with empty plasmid without NAPE as a control.
 Vehicle
Vehicle - Control
 PX866
PI3K inhibitor - medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes
 AdSort1
Over-expression of sortilin 1 protein
 AdSort1+PX866
Both PI3K inhibitor (medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes) and over-expression of sortilin 1 protein.
 Salicylamine
Salicylamine added to the drinking water at a concentration of 3g/L.
 ASO
Control anti-sense oligonucleotide
 ASO-1
Target anti-sense oligonucleotide (ASO)-1
 ASO-2
Target anti-sense oligonucleotide (ASO)-2
 HAb-Control
Control humanized antibody
 HAb-FGFR1
Humanized bispecific antibody that selectively activates FGFR1/ß Klotho complex
 Octreotide
Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone
 Pasireotide
Pasireotide (SOM230, trade name Signifor) is an orphan drug approved in the U.S. and Europe for the treatment of Cushing's disease in patients who fail or are ineligible for surgical therapy. It was developed by Novartis. Pasireotide is a...
 3AC
SHIP1 Inhibitor. SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is only found in hematopoietic lineage cells. 3AC is a...
 K118
3AC derivative also known as Soluable 3AC
 SAHA
Suberoylanilide hydroxamic acid - a histone deacetylase (HDAC) inhibitor
 CI994
Tacedinaline - a histone deacetylase (HDAC) inhibitor
 PEG-CBS
Polyethylene glycol cystathionine beta-synthase
 Water with PCA
Water with penicillamine
 ShK-186
Stichodactyla toxin that is a selective and potent blocker of the voltage-gated Kv1.3 channel
 pCMV6-FGFBP3
pCMV6 plasmid encoding for murine FGFBP3
 pCMV6
pCMV6 empty plasmid (control)
 pCMV6-FGFBP1
pCMV6 plasmid encoding for murine FGFBP1
 Metformin
Metformin is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, to decrease GI glucose absorption and to increase target...
 Peptide - Control
Control peptide
 Peptide - RGD
RGD Peptide
 PD2244
Centrally acting anti-inflammatory drugs for the treatment of Frontotemporal Dementia (FTD). These compounds are orally active. Their mechanism of action is inhibition of tumor necrosis factor-alpha (TNFa) via blockade of TNFa synthesis by...
 Angiotensin
Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin also stimulates the...
 pNAE
E. coli Nissle 1917 expressing pNAE to increase production of N-acylethanolamide (NAE) family of lipids
 shRNA - Becn1
shRNA-mediated knockdown of Beclin1 (Becn1)
 7,8-Dihydroxyflavone
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ˜ 320...
 Acetate
A salt or ester of acetic acid.
 Glycerol
Glycerol (also called glycerine or glycerin) is a simple polyol (sugar alcohol) compound.
 Acetate-Glycerol
Animals received both Acetate and Glycerol
 PD0325901
Inhibitor of the Raf-activated MAP/ERK kinase (MEK), Barrett et al. Bioorganic & Medicinal Chemistry Letters 2008
 SR1664
A PPARg antagonist. (S)-4'-((5-((1-(4-nitrophenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid.
 Ciprofloxacin-Metronidazole
A combination of ciprofloxacin with an antimicrobial agent active against anaerobes, such as metronidazole, treats a mixed aerobic/anaerobic infections.
 FG-4497
HIF prolyl-4-hydroxylase inhibitor
 AEA
N-arachidonoylethanolamine
 PEA
palmitoylethanolamide
 AEA-PEA
Combination of N-arachidonoylethanolamine and palmitoylethanolamide
 Imeglimin
Imeglimin is an experimental drug being developed as an oral anti-diabetic. It is an oxidative phosphorylation blocker that acts to inhibit hepatic gluconeogenesis, increase muscle glucose uptake, and restore normal insulin secretion.
 FGF-21
Fibroblast growth factor 21 is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the "endocrine" subfamily which includes...
 OEA-PEA
oleoylethanolamine and palmitoylethanolamide
 HDAC inhibitor
histone deacetylase inhibitor
 Digoxin
Digoxin is a purified cardiac glycoside similar to digitoxin extracted from the foxglove plant, Digitalis lanata. Digoxin is occasionally used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes...
 NEN
niclosamide ethanolamine salt
 HIF P-HI
HIF prolyl-hydroxylase inhibitors are members of a class of new drugs that act on the hypoxia-inducible factor (HIF) pathway.
 AgRP Peptide
Agouti-related peptide(AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. AgRP is a paracrine signalling molecule made up of 112 amino acids (the gene product of 132 amino acids is processed by removal of the N-terminal...
 Didox
Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia
 Doxorubicin
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks.
 FGF-19
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism
 Flavopiridol
Flavopiridol hydrochloride is a potent CDK (cyclin-dependent kinase), and a CDC25 phosphatase family inhibitor.
 JQ1
JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins
 osteocalcin
The drug that was administered during the study.
 Rapamycin
Sirolimus, also known as rapamycin, is a macrolide compound that has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It inhibits activation of T cells and B cells by reducing their sensitiv
 NV compound
The drug that was administered during the study.
 TZD
insulin sensitizer
 Clodronate
The drug that was administered during the study.
 siRNA
The drug that was administered during the study.
 miR128
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs.
 Atorvastatin
It can treat high cholesterol and triglyceride levels. This may reduce the risk of angina, stroke, heart attack, and heart and blood vessel problems.
 Furosemide
It can treat fluid retention (edema) and swelling caused by congestive heart failure, liver disease, kidney disease, and other medical conditions.
 Btk-B
specific BTK inhibitor
 VPA
Valproic acid (VPA) can treat seizures and bipolar disorder. It can also help prevent migraine headaches.
 Berberine
Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree tumeric. People take berberine for heart failure.
 Concanavalin A
Induces hepatitis
 Olive Oil
The drug that was administered during the study.
 VEGF-Trap
VEGF blocker
 Isoflurane
The drug that was administered during the study.
 D3
oral vitamin D3 supplement
 Carrageenan
Carrageenan was added to the drinking water. Carrageenan are a family of linear sulfated polysaccharides that are extracted from red edible seaweeds. They are widely used in the food industry, for their gelling, thickening, and stabilizing properties. Th
 DDT
DDT is a synthetic organic compound used as an insecticide. Like other chlorinated aromatic hydrocarbons, DDT tends to persist in the environment and become concentrated in animals at the head of the food chain.
 OOV
Olive oil vehicle
 ApoC3
experimental oligonucleotide that destabilizes an mRNA called ApoC3 that affects serum triglyceride clearance
 CVC
The drug that was administered during the study.
 CVC + RA
The drug that was administered during the study.
 IDE-A
Insulin-Degrading Enzyme (IDE) Compound A - Saghatelian, Alan
 IDE-B
Insulin-Degrading Enzyme (IDE) Compound B - Saghatelian, Alan
 IDE-C
Insulin-Degrading Enzyme (IDE) Compound C - Saghatelian, Alan
 BMP
Bone morphogenetic protein - induce the formation of bone and cartilage, orchestrate tissue architecture throughout the body. BMP-7 has recently found use in the treatment of chronic kidney disease (CKD) and has been shown in murine animal models...
 Cholic acid
Cholic acid is a bile acid - aids in digestion of fats and certain nutrients.
 NV
Proprietary compound from Navitor
 MC Tween
Chemical buffer
 Formestane
Formestane (trade name Lentaron), also known as 4-hydroxyandrost-4-ene-3,17-dione, is a type I, steroidal, selective aromatase inhibitor. It is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is...
 MP01
Proprietary compound from Metacrine
 UCB
Proprietary compound from UCB
 Cholesterol conjugated hsiRNA
Cholesterol was conjugated to hsiRNA (heterochromatic short interfering RNA).
 Premarin
Premarin is the brand name for an estrogen medication that consists of conjugated estrogens.
 PBS
Phosphate-buffered saline is a buffer salt solution containing disodium hydrogen phosphate and sodium chloride.
 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 AM6545
AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor and was developed for the treatment of obesity.
 IL-5, recombinant
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. This is the recombinant form of IL-5
 Ampicillin, Neomycin, Vancomycin
1g/L of Ampicillin, 1g/L of Neomycin, and 0.5g/L of Vancomycin mixed in water
 CL 316,243
A highly selective ß3 adrenoceptor agonist that has been shown to cause increases in brown adipose tissue thermogenesis and metabolic rate as well as decreases in blood insulin and glucose levels.
 1GHI
Proprietary compound from 1GHI.
 AST
Proprietary compound from Astellas
 IMG
Proprietary compound from Imagine
 siLuc
siRNA targeting luciferase
 let-7
The drug that was administered during the study.
 LbNOX
A water-forming NADH oxidase from Lactobacillus Brevis (Lb-NOX) is used as a genetic tool for inducing a compartment-specific increase of the NAD+/NADH ratio in human cells.
 Luciferase
An enzyme that catalyzes the oxidation of luciferin and ATP, producing light.
 CMP-NulO
anti-gonococcal therapeutic (CMP-nonulosonate)
 Compound 1
siRNA targeting proprietary gene of interest, from the lab of Ken Fujise - University of Cincinnati Medical Center client.
 MB1-47
MB1-47, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 MB1-78
MB1-78, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 MB1-98
MB1-98, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 MB1-103
MB1-103, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 MB1-105
MB1-105, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 MB5-1
MB5-1, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 MB5-6
MB5-6, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 2-Fucosyllactose
2'-Fucosyllactose is an oligosaccharide. It is the most prevalent human milk oligosaccharide (HMO), making up about 30% of all of HMOs.
 Monobutyrin
Prophorce SR710 - Gut health and performance enhancer based on monobutyrin
 Y05
Y05, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 WX06
WX06, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 Asprosin 1
Asprosin is a protein hormone produced by mammals in their fatty (white adipose) tissues during fasting that stimulates the liver to release glucose into the blood stream - isoform 1
 Asprosin 2
Asprosin is a protein hormone produced by mammals in their fatty (white adipose) tissues during fasting that stimulates the liver to release glucose into the blood stream - isoform 2
 Asprosin 3
Asprosin is a protein hormone produced by mammals in their fatty (white adipose) tissues during fasting that stimulates the liver to release glucose into the blood stream - isoform 3
 CCL4
Carbon tetrachloride used for inducing liver fibrosis
 Exendin-4
Exendin-4 is an incretin mimetic peptide, which is composed of 39 amino acids. It is an analog of glucagon-like peptide 1 (GLP-1), and an insulinotropic agent, with a long half-life. Exendin-4 has been used for the treatment of ob/ob mouse model t...
 ALULA
IgG2b isotype mouse monoclonal antibody against avß5; stock concentration 1.9 mg/ml
 2H6-2C IGg2B
control antibody (for comparison to ALULA); stock concentration 2.2 mg/ml
 Cefaperazone
Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
 Vancomycin
Vancomycin is used to treat colitis (inflammation of the intestine caused by certain bacteria) that may occur after antibiotic treatment. Vancomycin is in a class of medications called glycopeptide antibiotics. It works by killling bacteria in the...
 Neomycin
Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments, and eyedrops.
 Vancomycin, Neomycin
0.5 g/L Vancomycin and 1.0 g/L Neomycin combination
 Arsenic
A metallic element that forms a number of poisonous compounds
 VancNeo
cocktail of 0.5g/L Vancomycin and 1.0g/L Neomycin .
 Estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles.
 GABA
GABA (Gamma-Aminobutyric Acid) is the chief inhibitory neurotransmitter in the mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system. In humans, GABA is also directly responsible for...
 Astellas
Proprietary compound from Astellas.
 Txnip Inhibitor
Thioredoxin-interacting protein inhibitor
 Cisplatin
chemotherapy medication used to treat a number of cancers
 STZ
Streptozotocin (STZ) is an alkylating agent that targets insulin-producing beta cells in the pancreas, mimicking Type 1 diabetes phenotypes in mice.
 GDF-11
Growth Differentiation Factor 11 - This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family t
 RNAi-Agrp
RNA interference targeting the Agrp gene
 Ethanol
Ethanol
 Maltose dextrin
Maltodextrin is a polysaccharide that is used as a food additive.
 Acetaminophen
N-acetyl-para-aminophenol (APAP),Tylenol, Panadol. It belongs to a class of drugs called analgesics and antipyretics.
 WX53
WX53, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 M
The drug that was administered during the study.
 OU CMPD1
Ohio University custom compound 1, inhibitor of inflammation. The compound is proprietary to Ohio University.
 OU CMPD2
Ohio University custom compound 2, inhibitor of inflammation. The compound is proprietary to Ohio University.
 Soluble epoxide hydrolase (sEH) inhibitor
Soluble epoxide hydrolase (sEH) is an enzyme that catalyzes the hydrolysis of epoxyeicosatrienoic acids (EETs), which are lipid mediators derived from arachidonic acid through the cytochrome P450 epoxygenase pathway. Inhibitors sEH appear to reduce the
 TPPU
TPPU (N-[1-(1-oxopropyl)-4-piperidinyl]-N-[4-(trifluoromethoxy)phenyl)-urea) is a potent inhibitor of both human and mouse sEH.
 Y03
Y03, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution.
 CriPs
CRISPR-delivery particles (CriPs), composed of nano-size complexes of Cas9 protein and sgRNA that are coated with an amphipathic peptide called Endo-Porter that mediates entry into cells.
 ULM CMPD
ULM compound, hypocholesterolemic class.The compound is proprietary to ULM.
 HJB CMPD
The compound is proprietary to Hangzhou Just Biotherapeutics.
 HMO
Human milk oligosaccharides
 ABAT ASO
Hepatic specific GABA- transaminase (ABAT) anti-sense oligonucleotide (ASO).
 IL-2
regulates immunity response
 rat IgG
rat immunoglobulin antibody
 anti-NK1.1
antibody to NK1.1
 anti-ASGM1
antibody to ASGM1
 anti-PD-1
antibody to PD-1
 JR-AB2-011
JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 µM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 µM). JR-AB2-011 has anti-glioblastoma multiforme (GBM) properties
 PP242
Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kd or PI3Ka/ß/?, respectively. Torkinib (PP242) induces mitophagy and apoptosis.
 Tyloxapol
nonionic liquid polymer of the alkyl aryl polyether alcohol type
 Adiponectin (mouse), (recombinant)
ALX522–059; Enzo Life Sciences. Mimics serum adiponectin by forming high molecular weight (HMW) and hexameric species. Alternative names-Adipocyte complement related protein of 30kDa, ACRP30, AdipoQ, apM1, GBP28.
 PFOA
Perfluorooctanoic acid 95% pure. Perfluorooctanoic acid is a perfluoroalkyl acid commonly used in the preparation of fluoroacrylic esters, fluoropolymers and fluoroelastmers. It is found to be environmentally persistent and bioaccumulative with a long hal
 2,4-Dinitrophenol
2,4-Dinitrophenol (DNP) is a precursor to other chemicals and is biochemically active, inhibiting adenosine triphosphate (ATP) production in cells with mitochondria.
 trans-AUCB
This is a soluble epoxide hydrolase (sEH) inhibitor: 4-[[trans-4-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]cyclohexyl]oxy]-benzoic acid in 1% v/v PEG400
 BAM15
BAM15: N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine, a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage
 Niclosamide
Niclosamide: inhibits glucose uptake and oxidative phosphorylation
 EDC Mixture
The concentrations of the EDCs are atrazine (10 mg/kg), bisphenol-A (50 µg/kg), perfluorooctanoic acid (0.1 mg/kg), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (0.036 µg/kg)
 EP CMPD
The compound is proprietary to Energesis Pharmaceuticals.
 Doxycycline
Doxycycline is a broad-spectrum tetracycline-class antibiotic used in the treatment of infection.
 6-Sialyllactose
6'-Sialyllactose belongs to the class of organic compounds known as n-acylneuraminic acids. These are neuraminic acids carrying an N-acyl substituent. 6'-Sialyllactose is an extremely weak basic (essentially neutral) compound (based on its pKa). Sialyllac
 lactose-N-tetraose
Lacto-N-tetraose is a complex sugar found in human milk. It is one of the few characterized human milk oligosaccharides (HMOs) and is enzymatically synthesized from the substrate lactose. It is biologically relevant in the early development of the infant
 BT2
3,6-dichlorobenzo[b]thiophene-2-carboxylic acid
 ERAP1 Inhibitor
Inhibitor of Endoplasmic-reticulum associated aminopeptidase 1 (Maben et al Biochemistry and Molecular Biology 2018).
 Trulicity
Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist. It works by activating the GLP-1 receptor
 Sucrose + Fructose
sucrose + fructose (Acros Organic, New Jersey, NY)
 Rebaudioside A
Rebaudioside A is a steviol glycoside from the leaves of Stevia rebaudiana that is 240 times sweeter than sugar. Rebaudioside A is the sweetest and most stable steviol glycoside, and is less bitter than stevioside.
 Sucralose
Sucralose is an artificial sweetener and sugar substitute.
 Semaglutide
Semaglutide acts like human glucagon-like peptide-1 such that it increases insulin secretion, thereby increasing sugar metabolism.
 Semaglutide + EP CMPD
Semaglutide that was given in conjunction with the Energesis proprietary compound.
 Klotho
Naturally occurring human protein. Klotho is an enzyme that in humans is encoded by the KL gene. There are three subfamilies of klotho: a-klotho, ß-klotho, and ?-klotho. a-klotho activates FGF23, and ß-klotho activates FGF19 and FGF21. When the subfamily
 Empagliflozin
Empagliflozin is a SGLT2 class drug used in the treatment of type 2 diabetes
 DHT
Dihydrotestosterone is an endogenous androgen sex steroid and hormone, and agonist of the androgen receptor
 Curcumin
Anti-inflammatory dietary supplement
 TAS4464
A highly potent and selective inhibitor of NEDD8 activating enzyme (NAE).
 Clozapine N-oxide
Inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its
 Tetanus toxin
A bacterial protein toxin produced by Clostridium tetani.
 Resolvin D1
RvD1-Resolvin D1 is a resolvin that is docosa-4Z,9E,11E,13Z,15E,19Z-hexaenoic acid which is substituted by hydroxy groups at the 7, 8, and 17 positions (the 7S,8R,17S-stereoisomer). It has a role as an anti-inflammatory agent. It is a triol, a resolvin an
 GFP
Green Fluorescent Protein
 T3 (triiodothyronine)
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
 Livoletide
Levolitide/Livoletide (Millendo Therapeutics)- is intended to treat extreme hunger and obsession with food (hyperphagia) experienced by PWS patients. It is an analog of unacylated ghrelin (UAG) that is intended to work by decreasing the amount of the acti
 Carboxymethlcellulose 1%
Carboxymethlcellulose 1% (CMC). Carboxymethylcellulose is a cellulose derivative that consists of the cellulose backbone made up of glucopyranose monomers and their hydroxyl groups bound to carboxymethyl groups. It is added in food products as a viscosity
 Human Insulin
Novolin R Regular Human Insulin (rDNA Origin)
 LCVD-1
Lymphocystis disease virus-1 (LCDV-1), viral insulin/IGF-1-like peptides (VILPs)
 GIV
Grouper iridovirus (GIV), viral insulin/IGF-1-like peptides (VILPs)
 P54
P54 inhibits the induction of the enzyme NFkB, thereby inhibiting downstream inflammatory genes such as COX II and iNOS.
 Capsiate
Capsiate (CAP) is chemical analog of capsaicin.
 TNFa
Tumor Necrosis Factor-Alpha (TNFa) encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily.
 zVAD-FMK
Z-Val-Ala-DL-Asp-fluoromethylketone (zVAD-FMK) inhibited apoptosis induced by diverse stimuli.
 17ß-estradiol
E2, 50 µg in 25 µL of 5% ETOH/sesame oil
 Formoterol
Long-acting ß2 agonist (LABA) used as a bronchodilator in the management of asthma and chronic obstructive pulmonary disease (COPD)
 TNFa + zVAD-FMK
9 ug/kg/hr TNfa and 24 ug/kg/hr zVAD-FMK combination
 TNFa-20+zVAD-FMK-24
20 ug/kg/hr TNfa and 24 ug/kg/hr zVAD-FMK combination
 TNFa-40+zVAD-FMK-24
40 ug/kg/hr TNfa and 24 ug/kg/hr zVAD-FMK combination
 Liraglutide
Liraglutide is a recombinant DNA produced polypeptide analogue of human glucagon-like peptide-1 (GLP-1) which is used in combination with diet and exercise in the therapy of type 2 diabetes, either alone or in combination with other antidiabetic agents
 EGS2032
Proprietary compound of Energesis Pharmaceuticals.
 EGS2026+Liraglutide
Proprietary compound of Energesis Pharmaceuticals plus Liraglutide, which is an anti-diabetic medication.
 EGS2032+Liraglutide
Proprietary compound of Energesis Pharmaceuticals plus Liraglutide, which is an anti-diabetic medication.
 EGS2632+Liraglutide
Proprietary compound of Energesis Pharmaceuticals plus Liraglutide, which is an anti-diabetic medication.

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day
 µg/kg every other d
micrograms per kilograms every other day
 mg/kg 3X per wk
milligrams per kilograms 3 times per week
 mg/kg biweekly
milligrams per kilogram every other week
 mg/kg once
milligrams per kilogram one dose
 µg once
micrograms one dose
 µg/day
micrograms per day
 ng/mouse 2X wk
nangrams per mouse two times per week
 mg/kg
milligrams per kilogram
 %
% of drug in vehicle
 mg/ml
milligrams per milliliter
 ml/kg 3X per wk
milliliters per kilograms 3 times per week
 µg/kg BID
micrograms per kilograms twice per day
 g/L
grams per liter
 ppb
parts per billion
 µg twice
micrograms two doses
 g/kg
grams per kilogram
 µl once
microliters - one dose
 IU
International Units
 mU/kg/min
milliunits per kilogram per minute
 ug/kg/hr
micrograms per kilograms per hour

Experimental Factor: Experimental Group

 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.
 Control-Het
This animal belongs to the control group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Mouse Diet

 4wAIN76(LF)
AIN76 low-fat fed 4wks @ 3mos old
 4wAIN76(HF)
AIN76 high-fat fed 4wks @ 3mos old
 3mAIN76(LF0.15)
AIN76 low-fat 0.15% cholesterol fed 3mos @ 3mos old
 3mAIN76(HF0.18)
AIN76 high-fat 0.18% cholesterol fed 3mos @ 3mos old
 3mAIN76(LF0.1)
AIN76 low-fat 0.1% cholesterol fed 3mos @ 3mos old
 3mAIN76(HF0.3)
AIN76 high-fat 0.3% cholesterol fed 3mos @ 3mos old
 3mAIN76(LF0.1)early
AIN76 low-fat 0.1% cholesterol fed 3mos @ 4wks old
 3mAIN76(LF0.15)early
AIN76 low-fat 0.15% cholesterol fed 3mos @ 4wks old
 3mAIN76(HF0.18)early
AIN76 high-fat 0.18% cholesterol fed 3mos @ 4wks old
 3mAIN76(HF0.3)early
AIN76 high-fat 0.3% cholesterol fed 3mos @ 4wks old
 4mAIN76(LF0.02)
AIN76 low-fat 0.02% cholesterol fed 4mos @ 4wks old
 4mAIN76(LF0.0)early
AIN76 low-fat 0.0% cholesterol fed 4 months @ 4wks old
 4mAIN76(LF0.15)early
AIN76 low-fat 0.15% cholesterol fed 4 months @ 4wks old
 4mAIN76(LF0.3)early
AIN76 low-fat 0.3% cholesterol fed 4 months @ 4wks old
 4mAIN76(LF0.5)early
AIN76 low-fat 0.5% cholesterol fed 4 months @ 4wks old
 AIN76(LF)
AIN76 low-fat
 AIN76(HF)
AIN76 high-fat
 AIN76(LF0.15)
AIN76 low-fat 0.15% cholesterol
 AIN76(LF0.10)
AIN76 low-fat 0.10% cholesterol
 AIN76(HF0.18)
AIN76 high-fat 0.18% cholesterol
 AIN76(HF0.30)
AIN76 high-fat 0.30% cholesterol
 AIN76(LF0.02)
AIN76 low-fat 0.02% cholesterol
 AIN76(LF0.30)
AIN76 low-fat 0.30% cholesterol
 AIN76(LF0.50)
AIN76 low-fat 0.50% cholesterol
 AIN76(LF0.00)
AIN76 low-fat 0.00% cholesterol
 Surwit58Sucrose
Surwit 58% kcal fat with Sucrose (Research Diets D12331)
 LabDiet 5001
crude protein (23.0%), crude fat (4.5%), crude fiber (6.0%), Ash (< 8.0%), minerals (2.5%)
 Teklad - 8604
Harlan Teklad No.8604 (6% fat by weight)
 Teklad - 90221
Harlan Teklad No. 90221 75% chow, 7.5% casein, 7.5% cocoa butter, 2.5% dextrose, 1.625% sucrose, 1.625% dextrin, 1.25% cholesterol, 1.25% cellulose, 0.875% mineral mix (AIN-76), 0.25% vitamin mix (Teklad 40060), 0.125% choline chloride, and 0.5%...
 Western
Western Diet (Research Diets #D12079B)
 Surwit58Cornstarch
Surwit 58% kcal fat with cornstarch (Research Diets D12330)
 LabDiet 5008
crude protein (23.0%), crude fat (6.5%), crude fiber (4.0%), Ash (< 8.0%), minerals (2.5%)
 Teklad - 88137
Harlan Teklad TD.88137 (Western Diet)
 LabDiets 5LA6
NIH Rat & Mouse/Auto 11F 19.7% Protein, 12.2% Fat (ether extract), 13.1% Fat (acid hydrolysis), 4% Fiber, 6.3% Ash. Ingredients: ground wheat, wheat middlings, grounoats, dehulled soybean meal, fish meal, groun corn, soybean oil, corn gluten meal...
 LabDiet 5LG4
LabDiet JL Rat and Mouse/Irr 6F diet formulas used for breeding and maintenance at The Jackson Laboratory. Protein 19.3%, Fat (ether extract) 6.2%, Fat (acid hydrolysis) 7.2%, Fiber 4.3%, Ash 6.5% Ingredients: ground wheat, ground corn, wheat...
 LabDiet 5K52
LabDiet JL Rat and Mouse/Auto 6F This is a breeding diet used at the Jackson Laboratory. Protein 19.3%, Fat (ether extract) 6.2%, Fat (acid hydrolysis) 7.2%, Fiber 4.3%, Ash 6.5%. Ingredients: Ground wheat, ground corn, wheat middlings,...
 BioServ F3282
Rodent Hig Fat Diet. Protein 20.%, Fat 35.5%, Fiber 0.0%, Ash 3.2%, Moisture <5.0%, Carbohydrate 36.3%. Ingredients: Lard, Casein, Dextrose, Sucrose, DL-Methionine, Choline Chloride, Vitamin Mix and Mineral Mix
 Teklad - 7012
Crude Protein (Min) 19.0%, Crude Fat (Min) 5.0%, Crude Fiber (Max) 5.0%, Protein %19.92, Fat %5.67, Fiber %4.37, Ash %6.48, Ingredients - Ground corn, dehulled soybean meal, ground oats, wheat middlings, dehydrated alfalfa meal, soybean oil, corn...
 D1245i
Protein 24g 20kcal, Carbohydrate 41g 35kcal, Fat 24g 45kcal Ingredients: Casein, 80g, Mesh 200g, L-Cystine 3g, Corn Starch 72.8g, Maltodextrin-10 100g, Sucrose 172.8g,Cellulose (BW200) 50g, Soybean Oil 25g, Lard 177.5g, Mineral Mix (S10026) 10g...
 AIN76A
Also known as D10001. Protein 20.3g 20.8kcal, Carbohydrate 66.0g 67.7kcal, Fat 5.0g 11.5kcal Ingredients: Casein 200g, DL-Methionine 3g, Corn Starch 150g, Sucrose 500g, Cellulose (BW200) 50g, Corn Oil 50g, Mineral Mix (S10001) 35g, Vitamin Mix...
 Teklad - 2018S
Harlan-Teklad 2018S 18.8% protein (Calories : 23% protein, 17% Fat, 60% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast, dicalcium...
 Teklad - 93075
Harlan-Teklad TD.93075 Adjusted Calorie diet (Calories: 21% protein, 55% Fat, 24% Carbohydrate) A diet used to induce obesity. Approximate fatty acid profile (% total fat): 28% saturated, 30% trans, 28% monounsaturated (cis), 14% polyunsaturated...
 LabDiet 5058
PicoLab Mouse Diet 20, 20.0% protein (Calories: 23% protein, 22% Fat, 55% Carbohydrate)
 Teklad - 06414
Adjusted calories diet (Calories: 18.4% protein, 60.3% Fat, 21.3% Carbohydrate) Approx. 60% of total calories come from fat. Designed with similarities to Research Diets, Inc. formula D12492. For the series TD 06414-TD 06416. Approximate fatty aci...
 Dyets - 102238
Diet Induced Obesity Rodent Diet (Calories: 45% Fat)
 LabDiet PicoLab Rodent Diet 20
a regular chow diet comprising 23.6% protein, 11.9% fat, and 64.5% carbohydrates (PicoLab Rodent Diet 20, LabDiet)
 Research Diets - D03120501
Research Diets #D1245i + Cholesterol 0.235 gm, Alpha Lipoic Acid 1.42 gm, FD&C Yellow Dye #5
 Research Diets - D03120502
Research Diets #D1245i + Cholesterol 0.235 gm, FD&C Red Dye #1
 40 DNLF
10% fat as lard cornstarch based carbohydrate
 40 DNHF
45% fat as lard cornstarch based carbohydrate
 Research Diets - D12450B
Research Diets - D12450B Rodent Diet with 10% kcal% fat.
 Research Diets - D12451
Research Diets - D12451 Rodent Diet with 45% kcal% fat
 Research Diets - D06081502
Research Diets - D06081502 (45% of energy from fat + 1.2% quercetin)
 methionine restricted diet (0.17%)
Methionine restricted diet - 0.17% methionine, glutamic acid 3.39%, energy content 3.812 kcal/g, 18.9% of calories from fat, 64.9% carbohydrate, and 14.8% a custom mix of L-amino acid.
 methionine restricted diet (0.86%)
Methionine restricted diet - 0.86% methionine, L-glutamic acid 2.7%, energy content 3.812 kcal/g, 18.9% of calories from fat, 64.9% carbohydrate, and 14.8% a custom mix of L-amino acid.
 Atherogenic Diet
Developed by Dr. Bev Paigen. Contains 50% sucrose, 18.5% fat (butter), 1.0% cholesterol, and 0.5% cholic acid (wt/wt).
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat
 BioServ F1259SP
Bioserv Product# F1259SP. Liquid Rat Diet, LD82. Note that it has a higher fat content (17%) than standard diets. Corn Syrup Solids, Casein, Olive Oil, Maltodextrin, Cellulose, Mineral Mix, Corn Oil, Suspending Aids, Safflower Oil, Vitamin Mix,...
 Research Diets – D00110804C
Research Diets – D00110804C (Clinton/Cybulsky Rodent Diet with .02% Cholesterol)
 Research Diets - D10001
Research Diets - D10001 (AIN76A Chow plus Pioglitazone - 112.5mg/kg)
 LabDiet 5P75/5P76
Prolab 5P75 and 5P76 Isopro 3000 are the irradiated forms of RMH 3000 (5P00). The product has been irradiated to virtually bacteria-free dietary control. Protien 22.5%, Fat 5.4% Cholesterol 195 ppm
 BioServ S3888
Dox Diet, Grain-Based, Doxycycline added (200 mg/kg), Green, 1/2" Pellets, Sterile Ingredients: Ground Wheat, Ground Corn, Dehulled Soybean Meal, Wheat Germ, Fish Meal, Brewer's Dried Yeast, Corn Gluten Meal, Porcine Animal Fat (preserved with...
 Research Diets - D08060105
Custom Diet: 60% kcal from fat, 1.5% cholesterol, carb from cornstarch
 TestDiet - 58Y2
TestDiet 58Y2 with 10%Kcal fat as corn oil and lard.
 TestDiet - 58Y1
Diet Induced Obesity Rodent Purified Diete with 60% energy from fat (Lard).
 TestDiet - 5APD
TestDiet 5APD with 67 ppm MK-0626.
 TestDiet - 5APC
TestDiet 5APC with 67 ppm MK-0626
 Research Diet - D12450J
Rodent Diet with 10% kcal% fat. The fat comes from Lard and Soybean Oil
 Research Diets - D12468
Rodent Diet With 10 kcal% Soy Protein and 48 kcal% Lard
 Research Diets - D12108C
High fat rodent diet with 1.25% cholesterol. Fat source: Soybean Oil and Cocoa Butter. Used in Atherosclerosis research and often used with Apo E or LDLR knockout mice. Replaces D12108 with used alcohol-extracted casein, which is not believed t...
 Teklad - 2018
2018 Teklad Global 18% Protein Rodent Diet is a fixed formula, non-autoclavable diet manufactured with high quality ingredients and designed to support gestation, lactation, and growth of rodents. 2018 does not contain alfalfa, thus lowering the...
 Teklad - 2018 (cholic acid)
2018 Teklad Global 18% Protein Rodent Diet is a fixed formula, non-autoclavable diet manufactured with high quality ingredients and designed to support gestation, lactation, and growth of rodents. 2018 does not contain alfalfa, thus lowering the...
 Teklad - 08811
Harlan TD.08811 45%kcal Fat Diet (21% MF, 2% SBO) Designed with similaries to TD.88137 Western Diet with 21% anhydrous milk fat and 34% sucrose. 2% soybean oil is included to supplement essential fatty acids and the more modern AIN-93 mineral and...
 Teklad - 7912
Irradiated 7012 Teklad LM-485 Mouse/Rat Sterilizable Diet. Crude Protein 19.1%, Fat (ether extract) 5.8%, Crude Fiber 4.6%, Energy Density 3.1 kcal/g, Calories from Protein 25%, Calories from Fat 17%, Calories from Carbohydrate 58%. A fixed...
 Research Diets - D12079Bi
Irradiated version of D12079B. All values in gm%. Protein 20, Carbohydrate 50, Fat 21, Total kcal/gm 4.7, Casein, 80 Mesh 195, DL-Methionine 3, Corn Starch 50, Maltodextrin 10 100,Sucrose 341,Cellulose 50,Milk Fat,Anhydrous* 200,Corn Oil...
 Teklad - 8904
Irradiated diet of 8604. a fixed formula, non-autoclavable diet manufactured with high quality ingredients and designed to support gestation, lactation, and growth of rodents. Typical isoflavone concentrations (daidzein + genistein aglycone...
 Research Diets - D07031501
Rodent Diet With 45 kcal% Fat and Modification To 16% Fat (Mostly Safflower Oil or Butter Fat) With 5% Fat as Sucrose Polybehenate. Protein 21.8g, Carbohydrate 50.9g, Fat 16.1g
 Research Diets - D07031502
Rodent Diet With 45 kcal% Fat and Modification To 16% Fat (Mostly Safflower Oil or Butter Fat) With 5% Fat as Sucrose Polybehenate. Protein 21.8g, Carbohydrate 50.9g, Fat 16.1g
 Research Diets - D12109C
Atherogenic Rodent Diet With 1.25% Cholesterol, 0.5% Cholic Acid, and 17% (w/w) Cocoa Butter.
 Teklad - 08485
Harlan Teklad TD.08485 Low Fat Control Diet Purified Diet, Modification of TD.88137, Low Fat & No Added Cholesterol, Reduced Sucrose.
 Research Diets - D14071202
Custom diet with 45% High Fat +4% blueberry powder.
 Research Diets - D14071201
Custom diet with 45% High fat
 Research Diets - D14071203
Custom diet with 10% Low fat
 Dyets - 510072
Contains 0.86% methionine.
 Dyets - 510071
Contains 0.17% methionine
 Research Diets - D12359
Control Diet 11.5% fat, 10.4% protein, 78.1% carbohydrate
 Research Diets - D12369B
Ketogenic Diet 89.5% fat, 10.4% protein, 0.1% carbohydrate
 Research Diets – D05090701
High fat 54% chow
 Teklad - 2016
Harlan-Teklad 2016 16.4% protein (Calories : 22% protein, 12% Fat, 66% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast, dicalcium...
 Teklad - 2916
Harlan-Teklad 2916 (Irradiated) 16.4% protein (Calories : 22% protein, 12% Fat, 66% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...
 Teklad - 2918
Harlan-Teklad 2918 (Irradiated) 18.6% protein (Calories : 24% protein, 18% Fat, 58% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...
 LabDiet 5053
PicoLab Rodent Diet 20, 21.0% protein (Calories: 24.5% protein, 13.1% Fat, 62.4% Carbohydrate)
 Research Diets - D12331i
Surwit Diet 58 kcal% fat w/sucrose. Fat: Soybean Oil, Coconut Oil (Hydrogenated). D12331i is the irradiated form of diet of Research Diets - D12331
 Dyets - 110098
AIN76A diet supplemented with 1.1 g/kg choline chloride
 Dyets - 110184
AIN76A diet supplemented with 5 g/kg choline chloride
 Teklad - 88137 plus 60% fructose solution
Harlan Teklad TD.88137 (Western Diet) plus a 60% fructose water (w/v) solution
 Research Diets - A02082002B
Methionine/choline deficient diet with 60 kcal% fat for NASH Models
 Research Diets - A02082002B 2000 ppm NEN
Methionine/choline deficient diet with 60 kcal% fat for NASH Models supplemented with 2000 ppm niclosamide ethanolamine (NEN)
 JJR_CONTROL
based on AIN93G; caloric density=3.95 kcal/g
 JJR_KETO
Ketogenic diet (90% fat, 10% protein, 0.7% carbohydrate); caloric density= 6.53 kcal/g
 JJR_LOW CARB
low carbohydrate diet (70%fat, 20% protein, 10% carbohydrate); caloric density=5.61 kcal/g
 Dyets - 710260
This diet contains 1 Kcal/ml, of which 35% are fat derived, 11% derived from carbohydrate, 18% are derived from protein, & 36% are derived from ethanol. To 132.18 grams of Dyets #710260 add Ethanol (67 ml of 95% ethanol) and QS to one liter with...
 Research Diets - D12492i
Irradiated form of D12492, Rodent Diet with 60% kcal% fat.
 Research Diets - D14110101
Custom low fat (10% kcal) diet – dietary fiber(cellulose) matched to D14110103 20% kcal protein; 70% kcal carbohydrates; 10% kcal fat); energy density = 3.7 kcal/g
 Research Diets - D14110103
Custom high fat (45% kcal) diet- dietary fiber (cellulose) matched to D14110101 20% kcal protein; 35% kcal carbohydrate; 45% kcal fat) ; energy density = 4.5 kcal/g
 Research Diets - D11051801
Rodent Diet with 22% fat, 60% carbohydrate, 18% protein
 Research Diets - D11092301
Rodent Diet with 22% fat, 74% carbohydrate, 4% protein
 Research Diets - D11092310
Rodent Diet with 22% fat, 77% carbohydrate, 1% protein
 Research Diets - D10012M
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein
 Research Diets - D10012M 1500 ppm NEN
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 1500 ppm niclosamide ethanolamine (NEN)
 Research Diets - D10012M 2000 ppm NEN
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)
 Research Diets - D10012M 2000 ppm NEN & 2% COL
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 2000 ppm niclosamide ethanolamine (NLM) 2% colestyramine (COL)
 Research Diets - D12492 1500 ppm NEN
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 1500 ppm niclosamide ethanolamine (NEN)
 Research Diets - D12492 2000 ppm NEN
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)
 Research Diets - D12492 0.25% fruit
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 0.25% fruit extract
 Research Diets - D12492 0.5% fruit
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 0.5% fruit extract
 Safe - A03
Rodent diet destined for growing and breeding, pregnant and nursing animals. Wheat, maize, wheat bran, barley, extruded soybeans, soybean meal, hydrolyzed fish proteins, brewer’s yeast, calcium carbonate, pre-mixture of vitamins, pre-mixture of...
 Safe - A03VAL
Rodent diet destined for growing and breeding, pregnant and nursing animals. This diets is the same as Safe - A03 with the addition of 3% corn oil and 2.7% Valedia. Wheat, maize, wheat bran, barley, extruded soybeans, soybean meal, hydrolyzed...
 Teklad - 8640
Teklad 22/5 Rodent Diet - 8640 is a fixed formula, non-autoclavable diet manufactured with high quality ingredients and designed to support growth and reproduction of rodents. Typical isoflavone concentrations (daidzein + genistein aglycone...
 LabDiet 5LG6
65.4% Carbohydrate, 22.4% Protein, 12.2% Fat
 LabDiet 5LG6 - 17a-E2
LabDiet 5LG6 (65.4% CHO, 22.4% PRO, 12.2% FAT) supplemented with 17a-E2 (14.4 ppm).
 BioServ F3666
Ketogenic diet proportion of calories: 95.1% fat, 0.4% carbohydrate, 4.5% protein; energy density 7.456?kcal/g.
 LabDiet PicoLab Rodent Diet 5LOD
Crude Protein 23%, crude fat 4.5%, crude fiber 6.0%. Ingredients: dehulled soybean meal, ground corn, dried beet pulp, fish meal, ground oats, dehydrated alfalfa meal, cane molasses, brewers dried yeast, wheat germ, whey, porcine animal fat...
 Research Diets - D10012G
Research Diets - AIN-93G Rodent Diet with 15.8% fat, 63.9% carbohydrate, 20.3% protein
 JJR_HFD
based on TD.06414 60.3% fat, 18.3% protein, 21.4% carbohydrate); caloric density=5.1 kcal/g. Lard 4.650 kg, Casein 3.975 kg, Dextrine 2.400 kg, Sucrose 1.350 kg, Cellulose 0.983 kg, AIN-93G-MX Min Mx 0.720 kg, Soy Oil 0.450 kg, Calcium Phosphate,...
 LabDiet 5010
Autoclavable rodent diet 13.1% kcal fat, 58.2% kcal carbohydrate, 28.7% kcal protein
 Research Diets - D09032705G
Rodent diet 40% kcal fat, 43% kcal carbohydrate, 17% kcal protein
 Research Diets - D16012604
Rodent diet 40% kcal fat, 43% kcal carbohydrate, 17% kcal protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)
 Research Diets - D16012605
Rodent diet 40% kcal fat, 43% kcal carbohydrate, 17% kcal protein supplemented with 2000 ppm niclosamide ethanolamine (NEN) and 2% cholestyramine (COL)
 Research Diets - D12492 300 ppm NEN
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 300 ppm niclosamide ethanolamine (NEN)
 Research Diets - D12492 600 ppm NEN
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 600 ppm niclosamide ethanolamine (NEN)
 Harlan 2018
This is the food/chow mice were fed during the experiment.
 Low Fat
This is the food/chow mice were fed during the experiment.
 High Fat
This is the food/chow mice were fed during the experiment.
 High Fat + Glycan
This is the food/chow mice were fed during the experiment.
 Teklad - 97191
Harlan TD.97191 - ingredient matched control (for TD.95027) with ~0.6% calcium
 Teklad - 95027
Harlan TD.95027 low calcium diet
 Research Diets - D12331
58 kcal% fat w/sucrose Surwit Diet
 Research Diets - D12331 + RA
58 kcal% fat w/sucrose Surwit Diet plus Retinoic Acid
 Research Diets - D03021303i
High-fat diet with additional sucrose: 45 kcal% Fat and 25 kcal% Sucrose Special notes: Diet is irradiated with 10-20 kGy gamma-irradiation.
 Research Diets - D12079B
All values in gm%. Protein 20, Carbohydrate 50, Fat 21, Total kcal/gm 4.7, Casein, 80 Mesh 195, DL-Methionine 3, Corn Starch 50, Maltodextrin 10 100,Sucrose 341,Cellulose 50,Milk Fat,Anhydrous* 200,Corn Oil 10,Mineral Mix S
 Teklad - 7001
Rodent diet with 13% kcal fat, 53% kcal carbohydrate, 34% kcal protein
 Teklad - 2020X
Product Description- 2020X is a fixed formula, non-autoclavable extruded diet manufactured with high quality ingredients and designed to support gestation, lactation, and growth of rodents. 2020X does not contain alfalfa or soybean meal, thus...
 Teklad - 130588
Custom high fat diet (15.5% protein; 38.6% carbohydrate; 45.9% fat) @ 4.5 kcal/g using high amylopectin (100% glycemic starch)
 Teklad - 130587
Custom high fat diet (15.5% protein; 38.6% carbohydrate; 45.9% fat) @ 4.5 kcal/g using resistant starch (high amylose maize- 56% amylose). Estimated to be comprised of 20.1% resistant starch type 2.
 Teklad - 7004
Rodent diet with 29% kcal fat, 51% kcal carbohydrate, 20% kcal protein
 Research Diets - D16121601
Rodent Diet with 60% kcal fat, 20% kcal carbohydrate, 20% kcal protein supplemented with 300 mg/kg MB1-47, a deriviative of niclosamide ethanolamine (NEN)
 Research Diets - D17041902
Rodent Diet with 60% kcal fat, 20% kcal carbohydrate, 20% kcal protein supplemented with 150 mg/kg MB1-78, a deriviative of niclosamide ethanolamine (NEN)
 Research Diets - D16042102
60% fat (kcal) with 660 mg/kg Doxycycline
 LabDiet Prolab Isopro RMH 3000
Calories are 26.029% protein, 14.316% fat, and 59.655% carbohydrate. This is a companion diet to Prolab RMH 3000.
 Teklad TD.90228
Sodium deficient diet. Approximate nutrient content: 19% protein, 5% fat, 0.9% Ca, 0.65% P, 0.15% Mg, 0.8% K, and 0.07% Cl.
 Teklad TD.03095
High sodium diet. Approximate nutrient content: 19% protein, 5% fat, 0.9% Ca, 0.65% P, 0.15% Mg, 0.8% K, 1.6% Na, and 2.5% Cl.
 Research Diets - D12450J
Rodent Diet with 10% fat, 70% carbohydrate, 20% protein
 Research Diets - D17041404
Custom low fat (10% kcal) diet with inulin and cellulose (20% kcal protein; 70% kcal carbohydrates; 10% kcal fat); energy density = 3.7 kcal/g
 Research Diets - D08091803B
Custom high fat diet (45% kcal) with cellulose (20% kcal protein; 35% kcal carbohydrates; 45% kcal fat); energy density = 4.7 kcal/g
 Research Diets - D17041405
Custom high fat diet (45% kcal) with inulin and cellulose (20% kcal protein; 35% kcal carbohydrates; 45% kcal fat); energy density = 4.6 kcal/g
 Research Diets - D17012301
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 750 ppm MB1-47, a niclosamide derivative
 BioServ F0071
Protein 18.7%, Fat 5.6%, Fiber 4.7%, Ash 6.5%, Moisture <10%, Carbohydrate 59.1%; Calories: 3.6 kcal/gm
 Research Diets - D11092103
High fat high sucrose diet (HFHSD) composed of 36% fat derived-calories (9% corn oil and 27% butter) and 43.2% carbohydrate-derived calories with sucrose (30% sucrose-derived calories)
 Research Diets - D16012006
Research Diets - AIN-93M Rodent Diet with 9.4% fat, 75.9% carbohydrate, 14.7% protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)
 Research Diets - D17052302i
60% high fat and contains ursodeoxycholic acid, which is used as a cholagogue and choleretic.
 Bioserv F4031
Control for F1850/F3282 - Protein 20.5%, Fat 7.2%, Fiber 0%, Carbohydrate 61.6%
 Teklad - 08510
10% Fat Kcal Diet (ISP) -- The control diet in a series of diets with isolated soy protein, 10, 45, or 60% kcal from fat, with ~43% of the total carbohydrate from sucrose, and equivalent vitamin and mineral levels adjusted on an energy basis....
 Teklad - 08511
45% Fat Kcal Diet (ISP) -- The mid-fat diet in a series of diets with isolated soy protein, 10, 45, or 60% kcal from fat, with ~43% of the total carbohydrate from sucrose, and equivalent vitamin and mineral levels adjusted on an energy basis....
 BioServ S3282
Sterile form of BioServ F3282. Rodent High Fat Diet. Protein 20.%, Fat 35.5%, Fiber 0.0%, Ash 3.2%, Moisture <5.0%, Carbohydrate 36.3%. Ingredients: Lard, Casein, Dextrose, Sucrose, DL-Methionine, Choline Chloride, Vitamin Mix and Mineral Mix
 BioServ F1258SP
Rodent Liquid Diet, Lieber-DeCarli'82, Shake and Pour, Ethanol. Protein 151 kcal/Liter, Fat 135 kcal/Liter, Carbohydrate 1000 kcal/Liter, Ethanol 355 kcal/Liter
 Research Diets- D10042101
Research Diets- "Western" high fat/high sucrose diet, 1% cholesterol (fat source= cocoa butter and corn oil).
 JJR_ADA
ADA diet (20% fat, 20% protein, 60% carbohydrate); caloric density= 3.85 kcal/g
 JJR_Atkins
Atkins diet (55% fat, 30% protein, 15% carbohydrate); caloric density= 4.79 kcal/g
 JJR_Low Protein
Low protein(15% fat, 10% protein, 75% carbohydrate); caloric density= 3.77 kcal/g
 JJR_Zone
Zone diet (30% fat, 35% protein, 35% carbohydrate); caloric density= 4.03 kcal/g
 Teklad - 05230
This is modified from TD 88137 to reduce fat content (replaced with cornstarch and maltodextrin). % kcal from Protein 18.7, Carbohydrate 68.7, and Fat 12.6. Total Kcal/g is 3.7
 Teklad - 02028
Modification of TD.88137, to increase added cholesterol to 1.25% (total in the diet is 1.3%) and add 0.5% cholic acid, 15.4% kcal Protein, 41.9% kcal Carb, 42.6% kcal Fat
 BioServ F1850
Protein 20.5%, Fat 36%, Fiber 0%, Ash 3.5%, Moisture <10%, Carbohydrate 36.2%; Calories: 5.51 kcal/gm
 Research Diets - D12489B
Low fat condensed milk diet.. Protein 16.8 %kcal, Carbohydrate 72.6 %kcal, Fat 10.6 %kcal. Total kcal/gm 3.90
 Research Diets - D12079B + 20% Sucrose
All values in gm%. Protein 20, Carbohydrate 50, Fat 21, Total kcal/gm 4.7, Casein, 80 Mesh 195, DL-Methionine 3, Corn Starch 50, Maltodextrin 10 100,Sucrose 341,Cellulose 50,Milk Fat,Anhydrous* 200,Corn Oil 10,Mineral Mix S, plus 20% additional Sucrose
 Research Diets - D18110214
This is a custom diet based on the components of the “What we eat in America” diet. Protein 16%, Carbohydrate 57%, Fat 16%, Fiber 5.4%, Cholesterol 0.05%, Kcal/gm 4.4. Fat source is Soybean Oil (25g), Lard (75.6g), Butter (50.4g)
 Teklad-130852
Custom diet (17.7% protein; 60.1% carbohydrate; 7.2% fat) irradiated
 Teklad - 200354
Custom diet (17.7% protein; 60.1% carbohydrate; 7.2% fat) irradiated, with 5% Benefiber
 Teklad TD.190668
18.65% protein, 68.7% carbohydrate, and 12.6% fat as percent kcal, with 34% sucrose and 0.05% curcumin by weight
 Teklad TD-10014
15% anhydrous milk fat, 1% cholesterol, and 0.5% cholate
 AIN-93G (10%F)
Low fat diet control based on BioServ AIN- 93G 10%kcal fat, 20%kcal protein, 70%kcal CHO with 7% kcal sucrose
 AIN-93G (45%F)
High fat diet based on BioServ AIN- 93G 45%kcal fat, 20%kcal protein, 35%kcal CHO with 17% kcal sucrose
 HFHC
High fat/high cholesterol. 15% (w/w) High fat plus 1% (w/w) cholesterol
 Maternal breast milk
Breast milk from mother
 Research diet - D12450H
Rodent Diet With 10 kcal% Fat (Matching Sucrose to D12451) Protein 20% kcal, carbohydrate 70% kcal, energy density 3.82 kcal/g.
 Research diet - D16052504
Protein- 20% kcal, carbohydrate- 54% kcal, Fat 26% kcal
 Research diet - D11112201
Protein- 20% kcal, carbohydrate- 65% kcal, fat- 15% kcal
 Research diet- D19021107
Protein- 20% kcal, carbohydrate- 54% kcal, fat- 26% kcal.
 Purified lithogenic diet (PLD)
TD-04428, Teklad containing 19% fat (cocoa butter is the primary fat source), 1% cholesterol, 0.5% cholic acid, and essential minerals and vitamins
 LabDiet 5020
Mouse Diet 9F - 9% fat (Calories: 23.1% Protein, 21.6% Fat, 55.4% Carbohydrate)
 Teklad TD.89247
60% Fructose Diet - This formula is a modification of diet TD 78463 to increase zinc levels.
 Research Diet- D12450H
Rodent Diet with 10% fat, 70% carbohydrate, 20% protein
 Research Diets - D12451 (tallow)
Research Diets - D12451 Rodent Diet with 45% kcal% fat from tallow instead of lard
 Teklad - 210001
Custom diet (17.7% protein; 60.1% carbohydrate; 7.2% fat) irradiated, with 10% Benefiber
 LF WPI
Custom diet from laboratory. Low fat diet with whey protein isolate (WPI) as protein source
 45% HF WPI
Custom diet from laboratory. High fat (45%) diet with whey protein isolate (WPI) as protein source
 45% HF + 1.6% WPLC
Custom diet from laboratory. High fat (45%) diet with whey protein isolate (WPI) as protein source with 1.6% whey phospholipid component (WPLC)
 45% HF + 4 % WPLC
Custom diet from laboratory. High fat (45%) diet with whey protein isolate (WPI) as protein source with 4% whey phospholipid component (WPLC)
 45% HFD
Custom diet from laboratory. High Fat (45%) diet with Casein as protein source
 Envigo-TDCPP low dose
0.1 mg/kg TDCPP (Tris(1,3-dichloro-2-propyl)phosphate)
 Envigo-TDCPP high dose
831 mg/kg TDCPP
 Vehicle (0.1% DMSO)
Vehicle (0.1% DMSO)
 NASH Research Diet D17010103
Rodent Diet With 40 kcal% Fat, Protein 200 g, and Fiber 50g
 Teklad-2018 + 10% WPLC
Teklad 2018 supplemented with 10% Whey protein phospholipid concentrate (WPLC)
 45% HF + 10% WPLC
Custom diet from laboratory. High fat (45%) diet with whey protein isolate (WPI) as protein source with 10% whey phospholipid component (WPLC).
 Research Diet D12492 + CANA
HFD plus SGLT2i canagliflozin (CANA) mixed in diet (25 mg/kg/d)
 TD 88137 Envigo
Cholesterol (0.2% total cholesterol), total fat (21% by weight; 42% kcal from fat), high in saturated fatty acids(>60% of total fatty acids) and high sucrose (34% by weight)
 Teklad-95092
7% corn oil diet. Protein-18.8% kcal, Carbohydrate-63.9% kcal, Fat-17.2% kcal
 Teklad 96121
Protein-15.2% kcal, carbs-42.7% kcal, fat-42%, 1.25% cholesterol diet
 45% HFD-SFA
45% saturated fatty acid-rich high fat diet (HFD-SFA) with 15% triolein & 10% lard
 TD 95125
Envigo Iodine deficient diet supplemented with 0.15% propylthiouracil
 TD 97350
Envigo TD.95125 ingredient matched control without PTU and with iodine added at 0.7 mg/Kg from potassium iodate.
 4% NaCl Diet
Made by lab by adding 3% NaCl to 5001 LabDiet powder chow and formed into pellets
 Research Diets D06111102
High Fat/High Salt Diet
 Research Diet D18032701
Rodent diet with 60% kcal% fat and 0.083 g GSKG/kg Note: This is a special diet formulated by GlaxoSmithKline
 Teklad 2019
3.3 kcal/g, 19% protein, 9% fat, 44.9% Carbohydrates


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