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Experiment

Circulating cytokine levels in B6 mice induced with trauma
Summary Data Summary
Investigator Haudenschild, Dominik
Description To determine the ability of anti-inflammatory medications to decreased trauma
induced inflammation following bilateral femur fractures. Potential to apply to
patients following traumatic orthopedic injuries with the hopes of decreasing
the detrimental effects of systemic inflammation

Applicable research area(s): Cardiovascular, Immune response
Status Completed
Public Release 7/25/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals21
Experimental Conditions6
Catalog Items1
Curation Info (# flags)1
Phenotype Assays5
Phenotype Measurements105
Histology Images0
Publications0
Phenotypes4


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
21
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 LabDiet 5001
crude protein (23.0%), crude fat (4.5%), crude fiber (6.0%), Ash (< 8.0%), minerals (2.5%)

Experimental Factor: Surgical Procedure

 femur fracture
The femur is experimentally fractured.
 Unmanipulated
Control for surgical procedure where animal has not been manipulated

Experimental Factor: Tissue Source

 serum
serum
Experimental Factor Values


No documents found.


Mammalian Phenotype (MP) Terms
MPTermIDMPTermNameDefinitionOther Results
MP:0008553increased circulating tumor necrosis factor level
greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses| particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium [ISBN:0-8153-1691-7| MESH:D12.644.276.374.500.800]
MMPC Search Results
MP:0008560increased tumor necrosis factor secretion
increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses| particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium [ISBN:0-8153-1691-7| MESH:D12.644.276.374.500.800]
MMPC Search Results
MP:0008641increased circulating interleukin-1 beta level
increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes| macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane [MESH:D12.644.276.374.465.501.600]
MMPC Search Results
MP:0008657increased interleukin-1 beta secretion
increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes| macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane [MESH:D12.644.276.374.465.501.600]
MMPC Search Results

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