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Strain
C57BL/6J

Summary Data Summary
Official Name C57BL/6J
Common Name C57BL/6J
Description C57BL/6J is the most widely used inbred strain and the first
to have its genome sequenced. Although this strain is
refractory to many tumors, it is a permissive background for
maximal expression of most mutations. C57BL/6J mice are
resistant to audiogenic seizures, have a relatively low bone
density, and develop age related hearing loss. They are also
susceptible to diet-induced obesity, type 2 diabetes, and
atherosclerosis. Macrophages from this strain are resistant
to the effects of anthrax lethal toxin.
TypeCount
Child Strains 2
Experiments 153
Publications 2
External References 1



Experiments
OrderInvestigatorExperiment StatusMeasurements
18573Shlomo Melmed
Adiponectin concentration in C57BL/6J mice treated w/ somatostatin analogs / MSMCSMC0615
Completed29
16411Edward Medof
Body Composition of Daf -/-, C5aR-/-C3aR-/-, WT / MMMCWRU0914
Completed60
202Alyssa Hasty
Body Composition Order #202 4/9/04
Completed27
19681Eva Feldman
C57BL/6J mice on HFD treated w/ STZ / MEFUOM1115
Completed240
21899Miklos Peterfy
Circulating adiponectin levels in young and old B6 mice
In Progress76
22105Karen Ryan
Circulating corticosterone and IGF-1 levels in B6 mice treated with FGF-21
Completed72
21875Dominik Haudenschild
Circulating cytokine levels in B6 mice induced with trauma
Completed105
22093Dominik Haudenschild
Circulating cytokine levels in B6 mice induced with trauma and treated with flavopiradol
Completed170
22093Dominik Haudenschild
Circulating cytokine levels in B6 mice treated with LPS and JQ1
Completed420
22108Jin Shengkan
Circulating cytokine levels in B6 mice treated with NEN, metformin, and cholestyramine
Completed351
22018Karen Ryan
Circulating FFA and glycerol levels in B6 mice treated with FGF-21
Completed72
22169Jon Ramsey
Circulating FGF-21 levels in B6 mice fed ketogenic diet
Completed30
5679Giles Duffield
Circulating hormone and lipid levels in Id2 KO mice
Completed480
10911Giles Duffield
Circulating hormone and lipid levels in Id2 KO mice pt2
In Progress156
7707sanjeev kumar
Circulating insulin and leptin levels in B6 mice fed high fat diet treated with ShK-186
Completed66
2515sanjeev kumar
Circulating insulin levels after GTT in B6 mice treated with ShK-186
Completed32
2561sanjeev kumar
Circulating insulin levels after GTT in B6 mice treated with ShK-186 pt2
Completed40
22043Jin Shengkan
Circulating insulin levels in B6 mice treated with niclosamide
Completed16
22116Jin Shengkan
Circulating insulin levels in B6 mice treated with niclosamide ethanolamine
Completed20
21994Andreas Baumler
Circulating leptin levels in B6 mice fed high fat diet
Completed29
22070Amparo Villablanca
Circulating lipid levels in Atf3 KO mice fed high fat diet
Completed144
22125Jin Shengkan
Circulating lipid levels of C57 mice treated with niclosamide, cholestyramine, and metformin
Completed225
21807Jon Ramsey
Circulating metabolic and inflammatory marker levels in B6 mice fed ketogenic diet
Completed378
22047Karen Ryan
Circulating TC and TG levels in B6 mice fed low protein diet
Completed154
21760John Rutledge
Cognitive assessment of c57BL/6 and LDLr -/- mice on a western diet
Completed3240
16407David Hui
Cytokines in C57BL/6J injected w/ lacZ adenovirus or lpcat3 shRNA expressing adenovirus / NIU063115
Completed79
16407David Hui
Cytokines in C57BL/6J mice on various diets / NIU063115
Completed110
1747Mary Zutter
Echocardiography Order #1747 9/18/09
In Progress140
1748Jeff Rottman
Echocardiography Order #1748 9/18/09
In Progress510
1765Ji Ma
Echocardiography Order #1765 9/30/09
In Progress70
1767Ming-Zhi Zhang
Echocardiography Order #1767 10/2/09
In Progress80
939David Bader
Echocardiography Order #939 8/1/05
Completed153
22255Maria Marco
Effect effects of dietary starch and probiotics on plasma LBP in DIO mouse model
Completed40
16441Tiangang Li
Effect of PI3K inhibitor PX866 and over-expression of sortilin 1 on plasma lipoprotein profiles in WT / MTLKUMC0914B
Completed32
18510William Kerr
Energy Balance of DIO C57 w/ SHIPi injections / MWKSUNY0315
Completed384
2520Chi Bun Chan
Energy Balance/SABLE Order #2520 4/16/12
Completed351
13205Danny Winder
Energy Balance/SABLE Order#13205 7/22/14
Completed372
12047David Harrison
Energy Balance/SABLE/GTT Order #12047 3/13/14
Completed1764
12015Saptarsi Haldar
Energy Balance/SABLE/Oxymax Max Test Order #12015 2/4/14
Completed384
18590Stephen Wheatcroft
Energy Expenditure - Promethion
In Progress192
1500Richard O'Brien
Energy Expenditure Order #1500 4/16/08
Completed0
1722Muhammad Abdul-Ghani
Energy Expenditure Order #1722 7/13/09
In Progress680
18505Jay Horton
Fat absorption in BP2 KO / MJHUTSW0415
Completed12
18472Shuxia Wang
Fat absorption in CD47-/- males / MSWUK0315
Completed20
18575M. Michael Wolfe
Fat absorption in IGIPR KO males (control data uploaded) / MMWMHMC0515
Completed4
18490Michael Jurczak
Fat absorption in Park2 KO / MMJYU0315
Completed20
21820Leslie Crofford
Glucose Tolerance Test #21820 10/19/15
Completed3840
5675Sean Davies
Gut microbiome analysis- effect of colonization with E.coli strain overexpressing enzyme to overproduce anorexigenic lipids
Completed78
15392Trina Knotts
Gut microbiome analysis in wild-type C57BL/6J chow-fed mice: Effect of gut location(biogeography) and sequencing method on microbiota diversity
Completed60
18496Harini Sampath
Gut microbiota analysis: Effect of OGG1 knockout in Chow and HFD-fed mice
Completed24
13176Harini Sampath
Gut microbiota analysis: Effect of OGG1 knockout in chow-fed mice
Completed24
22044Xin Jie Chen
Hormone Measurements #22044 9/19/16
Completed64
944David Wasserman
Hyperglycemic Clamp Order #944 10/18/05
Completed1050
982David Wasserman
Hyperglycemic Clamp Order #982 10/18/05
Completed1050
836Aamir Zuberi
Hyperglycemic Insulinemic Clamp Order #836 1/31/05
Completed1439
26David Wasserman
HYPERINSULINEMIC CLAMP - HYPERINSULINEMIC CLAMP - V3005 PXN1218, V3005A PXN1218
Completed1591
13167April Stull
Hyperinsulinemic Clamp Order #13167 November 2014
Completed6066
1201Thomas W Gettys
Hyperinsulinemic Clamp Order #1207 8/16/06
Completed2503
1470Calvin Kuo
Hyperinsulinemic Clamp Order #1470 2/26/08
Completed3816
1848Thomas W Gettys
Hyperinsulinemic Clamp Order #1848 2/11/10
Completed816
18576Matthew Robinson
Hyperinsulinemic clamp Order #18576 ,January 2016
Completed5016
2090Thomas W Gettys
Hyperinsulinemic Clamp Order #2090 1/4/11
Completed4866
2259Carol MacKintosh
Hyperinsulinemic Clamp Order #2259 6/20/11
In Progress4831
2345Suzanne Jackowski
Hyperinsulinemic Clamp Order #2345 9/29/11
Completed4794
2413Jianping Ye
Hyperinsulinemic Clamp Order #2413 12/21/11
Completed5134
2436Joanne Tobacman
Hyperinsulinemic Clamp Order #2436 1/23/12
Completed4661
7704Dimitris Skokos
Hyperinsulinemic Clamp Order #7704 2/7/13
Completed4923
28David Wasserman
Hyperinsulinemic clamps - V3005 PXN1220
Completed197
18590Stephen Wheatcroft
Hyperinsulinemic Euglycemic clamp order #18590, November 2015
Completed5145
19704Vance Albaugh
Hyperinsulinemic Euglycemic clamp order #19704 September 2015
Completed3962
3647Nathan Rehmer
Hyperinsulinemic Euglycemic Clamp Order #3647 11/2/12
In Progress6524
2176Tae-Hwa Chun
Hyperinsulinemic Euglycemic Clamp Order#2176 2/8/11
Completed7782
1460Yuxiang Sun
Hyperinsulinemic-Euglycemic Clamp Order #1460 1/10/08
Completed711
22110Carl Johnson
Impact of High Fat Diet Choice on Energy Balance
Completed1248
22014John Rutledge
Influence of control or western diet on brain metabolites in C57bl/6 or LDLr-/- mice
Completed16
16424Riku Das
Intestinal Fat Absorption in Plasminogen knockout / MRDLRICC1014
Completed13
16446Natalie Torok
IPGTT insulin levels in C57 mice injected with shNOX4 adenovirus
Completed44
2520Chi Bun Chan
Leptin Injection/Food Intake/Mouse Weight Monitoring Order #2520 4/16/12
Completed192
2545Sue Bodine
Lipid droplet and mitochondrial analysis in aged MURF/1 KO Mice
Completed2
21744Prasad Gabbita
Lipid profile of DIO C57Bl/6J treated w/ PD2244 / MPGP2D1215
Completed300
18610Tuo Deng
Lipid profile, insulin levels of male adipocyte specific MHCII KO mice / MTDMHRI0815
Completed190
21858Jamie Fitzgerald
Lipid profiles and carcass body composition of C57BL/6-COL6A6 KO and +/- mice (MJFHFH0516)
Completed88
18605Shaodong Guo
Lipid profiles in FoxO1(S253A) transgenic mice / MSGTAMU0715
Completed204
21746Willa Hsueh
Lipid profiles of Adipoq-Cre(+); H2B fl/fl; LDLR-/- mice (MWHOSU0216-1)
Completed208
18572Darleen Sandoval
Lipid Profiles of CD 36 KO mice (thermoneutrality) / MSDDSUM0615
Completed152
22063Tiangang Li
Lipoprotein fractionation and CHOL of C57BL/6 mouse serum on lithogenic diet (MTLKUMC1016)
Completed16
18498Eva Feldman
Lipoprotein fractionation of C57BL/6J fed LFD,HFD,both / MEFUOM0215
Completed400
21799Eva Feldman
Lipoprotein fractionation of C57Bl6 mice on HFD with STZ tx (MEFUM0316)
Completed368
22061Darleen Sandoval
Liver Lipid extraction: C57Bl/6 male and female mice with or without bariatric surgery (MDSUM1016)
Completed280
5678Giles Duffield
Liver lipid levels in Id2 KO mice
Completed128
10912Giles Duffield
Liver lipid levels in Id2 KO mice pt2
Completed32
22126Jin Shengkan
Liver lipid levels of C57 mice treated with niclosamide
Completed36
18509Shaodong Guo
Liver lipids in FoxO1(S253A) transgenic mice / MSGTAMU0515
Completed0
18506Ruitang Deng
Liver lipids in in Nr1h4 and Esr1 KO / MRDURI0415
Completed48
16425David Hui
Liver lipids of C57BL/6J on different HFDs / NIU063116
Completed36
21745Zhiyong Lin
Liver lipids of KLF15 KO mice on ethanol diet/MJLCWRU1215
Completed138
22046Karen Ryan
Liver TC and TG levels in B6 mice treated with FGF21
Completed152
21976Karen Ryan
Liver TG and TC levels in FGF-21 treated C57 mice
Completed72
21835Karen Ryan
Liver TG measurements in B6 mice fed protein restricted diets
Completed128
21762Jin Shengkan
Liver TG measurements in B6 mice treated with metformin and niclosamide
Completed96
21811Holly Ingraham
Liver TG measurements in liver specific Nr5a2 KO mice fed high fat diet
Completed20
18587Jon Ramsey
Measurement of energy expenditure, RER and body composition in 12 month old mice placed on one of 3 diets(control (AIN93G), ketogenic (90% fat, 10% protein, 0.7% carbohydrate), or low carb (70%fat, 20% protein, 10% carbohydrate)) for 1 month.
Completed620
20726Jon Ramsey
Measurement of energy expenditure, RER and body composition in 28 month old mice on one of 3 diets (control (AIN93G), ketogenic, or low carbohydrate diets for 1 year.
Completed391
16437Wencheng Li
Metabolic measurements in B6 mice fed high fat diet
Completed45
21835Karen Ryan
Metabolic measurements in C57 mice on protein restricted diets
Completed128
21861Karen Ryan
Metabolic measurements in C57 mice treated with FGF21
Completed76
21864Jin Shengkan
Metabolic measurements in C57 mice treated with metformin and niclosamide
Completed96
20730Jin Shengkan
Metabolic measurements in HFD fed C57 mice treated with niclosamide and metformin
Completed160
22067Jon Ramsey
Metabolic measurements in p65Schc -/- mice
Completed868
19696Kei Sakamoto
Metformin clamp Order #19696, April 2015
Completed8462
13195Owen McGuinness
MMPC Energy Balance Study Order #13195 7/17/14
Completed525
16422Jon Ramsey
Muscle TG levels in Shc KO mice
Completed24
2577Jonathan Schoenecker
Oxymax Order #2577 6/28/12
Completed66
3629David Wasserman
Oxymax Part 1 Order #3629 10/17/12
Completed310
3629David Wasserman
Oxymax Part 2 Order #3629 10/17/12
Completed296
3617Carl Johnson
Oxymax/Black Box (Altered Light Dark Period) Order #3617 10/1/12
Completed88
7711John Stafford
Oxymax/Treadmill Max Test Order #7711 2/19/13
Completed104
1997Saptarsi Haldar
Oxymax/Treadmill Order #1997 8/13/10
Completed2935
18506Ruitang Deng
Plasma lipids in Nr1h4 and Esr1 KO / MRDURI0415
Completed151
13264John Rutledge
Plasma metabolomics in non-fasted control and Western diet fed WT and LDLRKO mice
Completed40
21976Karen Ryan
Plasma TG and TC levels in FGF-21 treated C57 mice
Completed72
7840Owen McGuinness
Ppar/Sable/GTT Order #7840 6/10/13
Completed3369
21814Owen McGuinness
Sable Energy Balance # 21814 10/1/15
Completed224
21820Leslie Crofford
Sable Energy Balance # 21820 10/19/15
Completed1078
22069Richard Simerly
Sable Energy Balance # 22069 12/5/16
Completed208
18576Matthew Robinson
Sable Energy Balance #18576 1/4/16
Completed560
21750David Wasserman
Sable Energy Balance #21750 4/13/15
Completed192
21752Italo Biaggioni
Sable Energy Balance #21752 1/18/16
Completed156
21809Owen McGuinness
Sable Energy Balance #21809 2/18/15
Completed576
21814Owen McGuinness
Sable Energy Balance #21814 8/28/15
Completed192
22023David Wasserman
Sable Energy Balance #22023 6/16/16
Completed1820
22039Richard Simerly
Sable Energy Balance #22039 9/8/16
Completed156
22044Xin Jie Chen
Sable Energy Balance #22044 9/19/16
Completed224
22069Richard Simerly
Sable Energy Balance #22069 10/14/16
Completed52
22076Anna Hemnes
Sable Energy Balance #22076 9/26/16
Completed532
22085John Stafford
Sable Energy Balance #22085 10/21/16
Completed336
22097David Wasserman
Sable Energy Balance #22097 11/14/16
Completed392
22123Richard Simerly
Sable Energy Balance #22123 12/19/16
Completed392
22180John Stafford
Sable Energy Balance #22180 3/6/17
Completed224
22216Anna Hemnes
Sable Energy Balance #22216 3/13/17
Completed210
22223Alyssa Hasty
Sable Energy Balance #22223 3/27/17
Completed224
22233Sophia Yu
Sable Energy Balance #22233 4/3/17
Completed224
18484David Wasserman
Sable Energy Balance 2/23/15 #18484
Completed288
18495David Jacobson
Sable Energy Balance 3/2/15 #18495
Completed192
13097Weiqin Chen
Sable Energy Balance 8/25/14 #13097
Completed156
7705David Wasserman
SABLE Order #7705 2/7/13
Completed154
7716John Stafford
SABLE Order #7716 2/21/13
Completed132
7752David Wasserman
Sable Order #7752 3/28/13
Completed142
16403Eva Feldman
Sucrose Freezing Medium Validation / MEFUOM0215
Completed96
1758Ming-Zhi Zhang
Tail Cuff Blood Pressure Order #1758 9/24/09
In Progress100
1788Richard Breyer
Tail Cuff Blood Pressure Order #1788 11/11/09
Completed60
16409Darleen Sandoval
Vsg / sham in Ppar alpha deficient males / NIU063111
Completed512
16406Darleen Sandoval
Vsg / sham in Ppar alpha deficient males / NIU063114
Completed377


External References
NameLink to Reference
Mouse Phenome Database: StrainsClick to view

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