mmpc-logo mmpc-logo
twitter-logo @NationalMMPC
| Create Account | login
Experiment

Effect of Niclosamide Derivatives on Energy Expenditure
Summary Data Summary
Investigator Shengkan, Jin
Description This study aims to determine if MB-X01Y03 and MB-WX-53 increase energy
expenditure in control (C57BL/6J) mice. For this thirty (30) male C57BL/6J mice
will be imported from JAX at ~ 8 weeks of age. After 1-week acclimation, mice
will be counterbalance by weight into 3 groups: Vehicle, MB-X01Y03 (5.0
mg/kg.day), and MB-WX-53 (2.5 mg/kg.day). On day one, mice will begin 4-day
daily gavage treatment and acclimated the CLAMS chamber.On day two, mice are
treated by gavage and transferred (in chamber) to acclimate to the CLAMS unit.
On day three and four, animals’ energy expenditure, physical activity, and food
intake will be assessed with daily gavage treatment.

Applicable research area(s): Diabetes, Metabolism, Obesity
Status Completed
Public Release 7/1/2023
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals30
Experimental Conditions5
Catalog Items3
Curation Info (# flags)1
Phenotype Assays31
Phenotype Measurements930
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
30
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Vehicle
Vehicle - Control
 WX53
WX53, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution
 Y03
Y03, a niclosamide derivative, in 2% DMSO, 10% solutol, 88% of 20% beta-cyclodextrin solution.

Experimental Factor: Drug Delivery Route

 PO
The drug was delivered orally

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor Values


No documents found.

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.