mmpc-logo
twitter-logo @NationalMMPC
| Create Account | login
Experiment

Metabolic measurements in B6 mice treated with metformin and niclosamide
Summary Data Summary
Investigator Shengkan, Jin
Description We had the C57BL6/J mice randomized into 4 groups. These mice were all fed on
high-fat diet (the Research Diets Inc. D12492) for 12 weeks. Group 1 is controls
without any treatment, including mice C1-C8. Group 2 is niclosamide treatment
group with oral treatment of niclosamide mixed into chow 2000ppm, including mice
N1-N8. Group 3 in metformin treatment group with oral treatment of metformin in
water to achieve dosage of 75 mg/kg/d, including mice M1-M8. Group 4 is
synergistic treatment group with both niclosamide and metformin treatment. Blood
samples were collected at age of 24 weeks after 16 hour fast. Each sample
contains ~50 micro liters of plasma.

Applicable research area(s): Metabolism
Status Completed
Public Release 6/14/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals32
Experimental Conditions8
Catalog Items2
Curation Info (# flags)1
Phenotype Assays3
Phenotype Measurements96
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
32
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Metformin
Metformin is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, to decrease GI glucose absorption and to increase target...
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat
 Research Diets - D12492 2000 ppm NEN
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)



No documents found.

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.