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Metabolic measurements in B6 mice treated with metformin and niclosamide
Summary Data Summary
Investigator Shengkan, Jin
Description We had the C57BL6/J mice randomized into 4 groups. These mice were all fed on
high-fat diet (the Research Diets Inc. D12492) for 12 weeks. Group 1 is controls
without any treatment, including mice C1-C8. Group 2 is niclosamide treatment
group with oral treatment of niclosamide mixed into chow 2000ppm, including mice
N1-N8. Group 3 in metformin treatment group with oral treatment of metformin in
water to achieve dosage of 75 mg/kg/d, including mice M1-M8. Group 4 is
synergistic treatment group with both niclosamide and metformin treatment. Blood
samples were collected at age of 24 weeks after 16 hour fast. Each sample
contains ~50 micro liters of plasma.

Applicable research area(s): Metabolism
Status Completed
Public Release 6/14/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
Experimental Conditions8
Catalog Items2
Curation Info (# flags)1
Phenotype Assays3
Phenotype Measurements96
Histology Images0


Strain NameCommon NameFemalesMalesUnknown

Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Drug Administered

Metformin is a drug approved by the U.S. Food and Drug Administration as a prescription medication to treat diabetes. This medication is used to decrease hepatic (liver) glucose production, to decrease GI glucose absorption and to increase target...
Vehicle - Control

Experimental Factor: Drug Dose Units

milligrams per kilograms per day

Experimental Factor: Experimental Group

This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat
 Research Diets - D12492 2000 ppm NEN
Rodent Diet with 60% fat, 20% carbohydrate, 20% protein supplemented with 2000 ppm niclosamide ethanolamine (NEN)

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)

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