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Experiment

Metabolic measurements in C57 mice treated with metformin and niclosamide
Summary Data Summary
Investigator Shengkan, Jin
Description We had the C57BL6/J mice randomized into 4 groups. These mice were all fed on
high-fat diet (the Research Diets Inc. D12492) for 12 weeks. Group 1 is controls
without any treatment, including mice C1-C8. Group 2 is niclosamide treatment
group with oral treatment of niclosamide mixed into chow 2000ppm, including mice
N1-N8. Group 3 in metformin treatment group with oral treatment of metformin in
water to achieve dosage of 75 mg/kg/d, including mice M1-M8. Group 4 is
synergistic treatment group with both niclosamide and metformin treatment. Blood
samples were collected at age of 24 weeks after 16 hour fast. Each sample
contains ~50 micro liters of plasma.

Applicable research area(s): Metabolism
Status Completed
Public Release 6/14/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals32
Experimental Conditions8
Catalog Items2
Curation Info (# flags)1
Phenotype Assays3
Phenotype Measurements96
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
32
0


Experimental Conditions
NameUnits
Drug Administeredone of [1GHI, 2-Fucosyllactose, ...]
Drug Dosearbitrary units (AU)
Drug Dose Unitsone of [%, µg once, ...]
Experimental Groupone of [Control, Control-Het, ...]
Fast Durationhour (hr)
Feeding Groupone of [Fasted, Fed, ...]
Mouse Dietone of [3mAIN76(HF0.18), 3mAIN76(HF0.18)early, ...]
Tissue Sourceone of [16-cell embryo, 2-cell embryo, ...]



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