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Experiment

2019-12-19 Carol Elias 32 Mice 3 Day CLAMS Run with Injections and T3 Water
Summary Data Summary
Investigator Allen, Susan
Description to pharmacologically test for differences in nutritional states. Mice body
composition taken before and after CLAMS. Animals fed on 5LOD (Standard Chow)
prior to CLAMS. HFD is fed to mice in CLAMS. 16 mice received saline injections
prior to 5pm, 8 mice received Levotilide injections at 5pm. Mice with T3 water
had water changed daily Monday-Wednesday before injections. Injections were
given by Elias Lab.
Status Completed
Public Release 3/10/2024
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flag
Data Analysis
TypeCount
Animals32
Experimental Conditions7
Catalog Items1
Curation Info (# flags)0
Phenotype Assays2
Phenotype Measurements13824
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
32
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Livoletide
Levolitide/Livoletide (Millendo Therapeutics)- is intended to treat extreme hunger and obsession with food (hyperphagia) experienced by PWS patients. It is an analog of unacylated ghrelin (UAG) that is intended to work by decreasing the amount of the acti
 Saline
Saline
 T3 (triiodothyronine)
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.
 SC
The drug was delivered subcutaneously.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Teklad - 2016
Harlan-Teklad 2016 16.4% protein (Calories : 22% protein, 12% Fat, 66% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast, dicalcium...
 Teklad - 88137
Harlan Teklad TD.88137 (Western Diet)
Experimental Factor Values


Phenotype Assays Add / Edit


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