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Experiment

2021-10-10 Olson-Ian CLAMS 12 mice 5 days
Summary Data Summary
Investigator Olson, David
Description We want to assess the affects of activating NOS1-PVH neurons that project to the
NTS on feeding and energy expenditure.
Status Completed
Public Release 12/20/2023
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals12
Experimental Conditions4
Catalog Items2
Curation Info (# flags)1
Phenotype Assays10
Phenotype Measurements42720
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
6
6
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Clozapine N-oxide
Inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its
 Saline
Saline

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet PicoLab Rodent Diet 5LOD
Crude Protein 23%, crude fat 4.5%, crude fiber 6.0%. Ingredients: dehulled soybean meal, ground corn, dried beet pulp, fish meal, ground oats, dehydrated alfalfa meal, cane molasses, brewers dried yeast, wheat germ, whey, porcine animal fat...
Experimental Factor Values


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