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Experiment

Cognitive effects of western diet in female c57BL/6J and LDLR -/- mice.
Summary Data Summary
Investigator Villablanca, Amparo
Description Female C57BL/6J and LDLR -/- (B6.129S7-Ldlr tm1Her/J) mice (~6 weeks of age)
were placed on control (TD.08485) or western diet (TD.88137) for two months.
Cognitive function was determined by y-maze Mice were adapted to testing room
for 30 min, were placed in the center of the Y-maze and were tracked with an
overhead camera for the extent of a 8-min trial. An elevated white plastic
Y-maze with three 35 cm arms at 120-degree angles. Entry into each arm was
counted and alternations and max alterations was determined. An alternation is
counted if the subject enters all arms consecutively without repeat. Max
alternation is the total number of possible alternations (total # of arm visits
-2). The % alternation score is the number of alternations divided by max
alternation and an indicator of spatial memory.
Status Completed
Public Release 12/12/2022
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals20
Experimental Conditions2
Catalog Items1
Curation Info (# flags)1
Phenotype Assays1
Phenotype Measurements20
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
10
0
0
C57BL/6J-Ldlr-/-
10
0
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Teklad - 2918
Harlan-Teklad 2918 (Irradiated) 18.6% protein (Calories : 24% protein, 18% Fat, 58% Carbohydrate) Ingredients—Ground wheat, ground corn, wheat middlings, dehulled soybean meal, corn gluten meal, soybean oil, calcium carbonate, brewers dried yeast,...
 Teklad - 88137
Harlan Teklad TD.88137 (Western Diet)
Experimental Factor (Units)
Experimental Group
Mouse Diet
Experimental Factor Values


Phenotype Assays Add / Edit


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