mmpc-logo
twitter-logo @NationalMMPC
| Create Account | login
Experiment

Cognitive assessment of c57BL/6 and LDLr -/- mice on a western diet
Summary Data Summary
Investigator Rutledge, John
Description Recent work suggests that diet and its effect on systemic and brain metabolism
impacts cognitive function and predisposition to dementia. We hypothesized that
diet or genetic predisposition to hyperlipidemia perturbs brain metabolism and
induces neuroinflammation that impairs cognitive performance. Therefore we first
aim to determine if and how western diet and/or LDLr-/- influence cognitive
function. C57BL/6 or LDLr-/- mice are subjected to either a Western diet or
control diet starting at 8 weeks of age for 3 months then subjected to morris
water maze and alternating y-maze.

Mice homozygous for the LKLr mutation have elevated cholesterol and TGRL and are
prone to dementia.

Applicable research area(s): Cardiovascular, Neurobiology
Status Completed
Public Release 4/18/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagExperiment Description
Data Analysis
TypeCount
Animals60
Experimental Conditions5
Catalog Items2
Curation Info (# flags)1
Phenotype Assays3
Phenotype Measurements3240
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
30
0
C57BL/6J-Ldlr-/-
0
30
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Teklad - 08485
Harlan Teklad TD.08485 Low Fat Control Diet Purified Diet, Modification of TD.88137, Low Fat & No Added Cholesterol, Reduced Sucrose.
 Teklad - 88137
Harlan Teklad TD.88137 (Western Diet)

Experimental Factor: Session (day)

 session
The session day for the Radial Arm Water maze

Experimental Factor: Trial Number

 trial #
Trial number for the Morris Water maze

Experimental Factor: Trial Type

 probe
Probe trial type for Morris water maze.
 test
Test trial type for Morris water maze.
 visible
Visible trial type for Morris water maze.



No documents found.

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.