mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Experiment

Circulating insulin levels after GTT in B6 mice treated with ShK-186
Summary Data Summary
Investigator kumar, sanjeev
Description C57BL6/J mice aged 8–9 wk were obtained from Harlan Laboratories and started on
Teklad TD.88137 together with 60% fructose/water (wt/vol) available ad libitum.
ShK-186 was administered by s.c. injection every other day. At 22 weeks of age
the mice were fasted for 8h and given a ip dose of 2g/kg glucose. Serum samples
were collected at 0 and 15 min.

Applicable research area(s): Diabetes, Metabolism
Status Completed
Public Release 5/15/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flaghas-doc-data-flagSame StrainAnimal CountExperiment Description
Data Analysis
TypeCount
Animals16
Experimental Conditions9
Catalog Items1
Curation Info (# flags)3
Phenotype Assays1
Phenotype Measurements32
Histology Images0
Publications0
Documents1
Phenotypes1


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
16
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 ShK-186
Stichodactyla toxin that is a selective and potent blocker of the voltage-gated Kv1.3 channel
 Vehicle
Vehicle - Control

Experimental Factor: Drug Dose Units

 µg/kg every other d
micrograms per kilograms every other day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.
 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Teklad - 88137 plus 60% fructose solution
Harlan Teklad TD.88137 (Western Diet) plus a 60% fructose water (w/v) solution

Experimental Factor: Tissue Source

 serum
serum
Experimental Factor Values


Phenotype Assays Add / Edit


Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.