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Experiment

Hyperinsulinemic Clamp Order #1207 8/16/06
Summary Data Summary
Investigator Gettys, Thomas W
Description The dietary flavanoid, quercetin ameliorates the development and progression of
artherosclerotic plaques in mice fed high fat diets. Our hypothesis is that this
dietary flavanoid will ameliorate the development of diet-induced insulin
resistance in this model.

1. ApoE null mice exhibit increased mitochondrial function in mouse skeletal
muscle.
2. Diminished formation and progression of artherosclerotic plaques in ApoE null
mice.

Applicable research area(s): Diabetes, Cardiovascular
Status Completed
Public Release 6/23/2011
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainNo dataExperiment Description
Data Analysis
TypeCount
Animals51
Experimental Conditions5
Catalog Items1
Curation Info (# flags)3
Phenotype Assays19
Phenotype Measurements2503
Histology Images0
Publications0
Phenotypes5


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
27
0
Apoe-/-
0
24
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 Research Diets - D06081502
Research Diets - D06081502 (45% of energy from fat + 1.2% quercetin)
 Research Diets - D12450B
Research Diets - D12450B Rodent Diet with 10% kcal% fat.
 Research Diets - D12451
Research Diets - D12451 Rodent Diet with 45% kcal% fat
Experimental Factor Values


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