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Experiment

Liver lipids in B6 mice fed high fat diet and treated with human milk
oligosaccharides Part 2
Summary Data Summary
Investigator Lee, Sunhye
Description The objective of this study was to investigate the beneficial effects of HMOs on
metabolic and cognitive functions in high fat fed mice. Mice (6 weeks old) were
acclimated for 1 week and divided into 2 groups as follows, and fed individual
diets for 12 weeks. HMOs were provided in diets.
2 groups
45% high fat, 17% Sucrose
45% high fat, 17% Sucrose + 10% HMOs

After 6-hour fasting, mice were sacrificed by cardiocentesis after being
anesthetized by pentobarbital. Plasma was collected using heparinized tubes and
tissues (liver, visceral fats, small intestines, colon, cecum contents, brain,
nodose ganglion) were collected for analysis.
Status Completed
Public Release 8/28/2021
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals8
Experimental Conditions9
Catalog Items1
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements16
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
8
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 HMO
Human milk oligosaccharides
 No Drug/Treatment
No Drug or Treatment done on these samples

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 %
% of drug in vehicle

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Research Diets - D12451
Research Diets - D12451 Rodent Diet with 45% kcal% fat

Experimental Factor: Tissue Source

 liver
liver


Phenotype Assays Add / Edit


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