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Experiment

Liver glutathione peroxidase and reductase activity in tx-J mice
Summary Data Summary
Investigator Kieffer, Dorothy
Description For progeny A131-A143, A154-A158, A509, A510, A515...Virgin females placed on
AIN76 with normal choline (1.1 g/kg choline chloride) 2 weeks prior to breeding
and remained on diet until progeny weaned, progeny weaned onto AIN76 with normal
choline (1.1 g/kg choline chloride)until tissues harvested. For progeny
A426-458...Virgin females placed on AIN76 with added choline (5 g/kg choline
chloride) 2 weeks prior to breeding and remained on diet until progeny weaned,
progeny weaned onto AIN76 with added choline (5 g/kg choline chloride) until
tissues harvested. For progeny A235-A254...Virgin females placed on AIN76 with
added choline (5 g/kg choline chloride) 2 weeks prior to breeding and remained
on diet until progeny weaned, progeny weaned onto AIN76 with normal choline (1.1
g/kg choline chloride) until tissues harvested. Penicillamine administered via
drinking water to select tx-J groups @ ~12 weeks of age until tissue harvest.

Applicable research area(s): Metabolism
Status Completed
Public Release 11/15/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals59
Experimental Conditions8
Catalog Items2
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements118
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C3He-Atp7btx-J/J
32
27
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 No Drug/Treatment
No Drug or Treatment done on these samples
 Water with PCA
Water with penicillamine

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 AIN76A
Also known as D10001. Protein 20.3g 20.8kcal, Carbohydrate 66.0g 67.7kcal, Fat 5.0g 11.5kcal Ingredients: Casein 200g, DL-Methionine 3g, Corn Starch 150g, Sucrose 500g, Cellulose (BW200) 50g, Corn Oil 50g, Mineral Mix (S10001) 35g, Vitamin Mix...

Experimental Factor: Tissue Source

 liver
liver
Experimental Factor Values


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