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Strain

C3H/HeJ-Atp7b^tx-J/J

Summary

Data Summary

Official Name	C3H/HeJ-Atp7b^tx-J/J
Common Name	C3He-Atp7b^tx-J/J
Description	The mutation comprises a G to A base substitution at position 2135 in exon 8 of the gene. This is predicted to result in a Gly712Asp missense mutation in the second putative membrane-spanning domain of the encoded protein.
Development Status	Phenotyping ongoing
Creation Method	spontaneous
Breeding Type	intercross

Type	Count
Investigators	1
Genomics - Modifications	1
Experiments	13

Investigators

Name	Institution
Noreene Shibata	University of California - Davis

Genomic Information

Gene	Allele 1	Allele 2	Protocol
Atp7b	point mutation - transition	point mutation - transition	Not Specified

OrderID	Order	Investigator	Experiment	Status	Measurements
11003	11003	Valentina Medici	Circulating ALT and AST levels in tx-J KO mice	Completed	173
13239	13239	Noreene Shibata	Circulating ALT levels in tx-J mice	Completed	45
14366	14366	Noreene Shibata	Circulating ALT levels in tx-J mice part 2	Completed	32
18566	18566	Noreene Shibata	Circulating ALT levels in tx-J mice Part 3	Completed	74
30503	30503	Noreene Shibata	Circulating lipid levels in Atp7b KO mice fed high fat diet	Completed	525
14368	14368	Noreene Shibata	Circulating TC and TG levels in tx-J mice	Completed	148
21972	21972	Noreene Shibata	Circulating TG levels in tx-J mice treated with penicillamine	Completed	43
22026	22026	Dorothy Kieffer	Liver glutathione peroxidase and reductase activity in tx-J mice	Completed	118
30504	30504	Noreene Shibata	Liver lipid levels in Atp7b KO mice fed high fat diet	Completed	150
22254	22254	Dorothy Kieffer	Liver protein carbonyl levels in tx-J mice.	Completed	59
14367	14367	Noreene Shibata	Liver TC and TG levels in tx-J mice	Completed	130
2422	2422	Valentina Medici	Liver TG levels in Atp7btx-J mice	Completed	23
22254	22254	Dorothy Kieffer	Liver thioredoxin and thioredoxin reductase levels in tx-J mice	Completed	68

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