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Experiment

Circulating ALT levels in tx-J mice
Summary Data Summary
Investigator Shibata, Noreene
Description The C3HeB/FeJ-Atp7b/J is a genetic mouse model of Wilson disease in humans. It
is being used to investigate the effect of maternal dietary methyl-group
supplementation, with or without copper-chelating agent
administration, on markers of DNA methylation in fetuses and offspring. Studies
in this model will open the possibility to 1) explain the effect of nutrition on
clinical manifestations of WD and other genetic diseases, and 2) study
epigenetic mechanisms of gene expression regulation and their effects on disease
phenotype.
Status Completed
Public Release 1/27/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals45
Experimental Conditions8
Catalog Items1
Curation Info (# flags)1
Phenotype Assays1
Phenotype Measurements45
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C3He-Atp7btx-J/J
20
25
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Vehicle
Vehicle - Control
 Water with PCA
Water with penicillamine

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 LabDiet 5001
crude protein (23.0%), crude fat (4.5%), crude fiber (6.0%), Ash (< 8.0%), minerals (2.5%)

Experimental Factor: Tissue Source

 plasma (EDTA)
plasma (EDTA)
Experimental Factor Values


Phenotype Assays Add / Edit


No documents found.

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