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Experiment

Liver thioredoxin and thioredoxin reductase levels in tx-J mice
Summary Data Summary
Investigator Kieffer, Dorothy
Description For progeny A131-A143, A154-A158, A509, A510, A515...Virgin females placed on
AIN76A with normal choline (1.1 g/kg choline chloride) 2 weeks prior to breeding
and remained on diet until progeny weaned, progeny weaned onto AIN76A with
normal choline (1.1 g/kg choline chloride)until tissues harvested.

For progeny A235-A254...Virgin females placed on AIN76A with added choline (5
g/kg choline chloride) 2 weeks prior to breeding and remained on diet until
progeny weaned, progeny weaned onto AIN76A with normal choline (1.1 g/kg choline
chloride) until tissues harvested.

Penicillamine administered via drinking water to select tx-J groups @ ~12 weeks
of age until tissue harvest.

AIN76A with 1.1 g/kg choline chloride also known as Dyets - 110098.
AIN76A with 5 g/kg choline chloride also known as Dyets - 110184.
Status Completed
Public Release 4/11/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal CountInconsistent MetaMouse DietNeed Conditions
Data Analysis
TypeCount
Animals34
Experimental Conditions10
Catalog Items2
Curation Info (# flags)5
Phenotype Assays2
Phenotype Measurements68
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C3He-Atp7btx-J/J
20
14
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 No Drug/Treatment
No Drug or Treatment done on these samples
 Water with PCA
Water with penicillamine

Experimental Factor: Drug Delivery Route

 Drinking Water
The drug was delivered in the drinking water.

Experimental Factor: Drug Dose Units

 mg/kg/d
milligrams per kilograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Dyets - 110098
AIN76A diet supplemented with 1.1 g/kg choline chloride

Experimental Factor: Mouse Diet - Maternal

 Dyets - 110098
AIN76A diet supplemented with 1.1 g/kg choline chloride
 Dyets - 110184
AIN76A diet supplemented with 5 g/kg choline chloride

Experimental Factor: Tissue Source

 liver
liver
Experimental Factor Values


Phenotype Assays Add / Edit


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