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Experiment

Endotoxemia in obese and lean mice following acute radiation exposure

Summary

Data Summary

Investigator	Murphy, William
Description	Radiosensitivity of lean and obese mice to acute radiation exposure. Obesity environment produces high level of pro-inflammatory cytokines which could exacerbate effects of radiation exposure. We hypothesize that GI tract and liver would be the main target tissues for inflammation post-radiation. Male C57BL/6NTac were fed either 10% LFD (D12450J) or 60% HFD (D12492) for 4 months. Animals on both diets were divided into 3 groups : control and 2 doses of X-ray (TBI 800 cGy and 1050 cGy); mice were euthanized and tissues obtained on day 3 post-radiation. Applicable research area(s): Obesity
Status	Completed
Public Release	3/13/2019
Animal Age	Measured In: week(s) post-natal (w)
Flags

Data Analysis

DOWNLOAD ALL DATA (.csv)

Type	Count
Animals	18
Experimental Conditions	5
Catalog Items	2
Curation Info (# flags)	2
Phenotype Assays	1
Phenotype Measurements	54
Histology Images	0
Publications	0
Documents	1

Animals

Strain Name	Common Name	Females	Males	Unknown
C57BL/6NTac	C57BL/6NTac	0	18	0

Animals/Strains

Experimental Factors

	Categorical Values
	Name / Abbreviation	Description
	Experimental Factor: Experimental Group
	Control	This animal belongs to the control group for the experiment.
	Experiment	This animal belongs to experimental group that is homozygous for gene manipulations.
	Experimental Factor: Mouse Diet
	Research Diet - D12450J	Rodent Diet with 10% kcal% fat. The fat comes from Lard and Soybean Oil
	Research Diets - D12492	Rodent Diet with 34% Fat, 60% kcal from Fat
	Experimental Factor: Radiation Type
	X-ray	Used X-rays as the radiation type for the experiment.

Experimental Factor (Units)
Experimental Group
Mouse Diet
Radiation Dose (cGy)
Radiation Type
Time Since Baseline (day)

Experimental Factor Values

Phenotype Assays Add / Edit

Name	Abbreviation
lipopolysaccharide binding protein (LBP) concentration	LBP conc

No documents found.

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