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Strain

C57BL/6NTac

Summary

Data Summary

Official Name	C57BL/6NTac
Common Name	C57BL/6NTac
Description	C57BL/6 litters were received in 1991 at F151 from the NIH Animal Genetic Resource. Cesarean derived in 1991 at Taconic, a foundation colony is maintained in gnotobiotic isolators. Origin is as follows: to NIH in 1951 from Jax at F32; to Jax in 1948 from Hall.
Development Status	Phenotyping complete
Phenotype Description	C57BL/6NTac substrains carry the Crb1Rd8 mutation. Retinal degeneration 8, is a mild form of retinal degeneration that affects vision. This recessive mutation is a single base pair mutation in the Crb1 gene, Crb1Rd8 (Mehalow et al. 2003) The onset of the phenotype appears to be between 2 and 6 weeks of age (Pritchett-Corning, 2012). C57BL/6J mice present a deletion (~17 Kbp) in the Nicotinamide Nucleotide Transhydrogenase (Nnt) gene. Nnt is a transmembrane protein that catalyzes the inter conversion of NADH and NADPH in the mitochondria. Studies suggest that the presence of Nnt is essential for mitochondrial defense against oxidative stress and for normal cellular metabolism (Huang et al. 2006). Taconic’s C57BL mice, including C57BL/6JBomTac, C57BL/6NTac and C57BL/10SgSnAiTac, or our B6D2F1 and B6129F1, do not carry the Nnt mutation which is present in C57BL/6J sub-strain.

Type	Count
Experiments	6

OrderID	Order	Investigator	Experiment	Status	Measurements
30394	30394	Jaume Padilla	Circulating glucose and insulin levels in Traf3ip2 KO mice fed high fat diet	Completed	162
30660	30660	Arta Monjazeb	Circulating HbA1c, glucose, FFA and leptin levels in C57BL/6N Tac mice fed HFD	Completed	104
22168	22168	Nicholas DiPatrizio	Circulating inflammatory markers in B6 mice fed high fat diet and treated with AM6545	Completed	310
22461	22461	William Murphy	Effect of antibiotic treatment on obesity-driven changes in gut permeability and metabolic endotoxemia-strain comparison	Completed	126
22158	22158	William Murphy	Endotoxemia in obese and lean mice following acute radiation exposure	Completed	54
22158	22158	William Murphy	Intestinal permeability in obese and lean mice following acute radiation exposure	Completed	48

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