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Experiment

mice with hypercholesterolemia lose cortical and trabecular bone in the femurs
and vertebrae
Summary Data Summary
Investigator Pelton, Kristine
Description A role for hypercholesterolemia in the development of osteoporosis has been
suggested in published reports. However, few studies contain direct evidence of
a role for maintenance of cholesterol homeostasis in bone health. Using
isocaloric high-fat/high-cholesterol and low-fat/no-cholesterol diets in a
4-month feeding study combined with micro computed tomography analysis, we
demonstrated in two different mouse strains that mice with hypercholesterolemia
lose cortical and trabecular bone in the femurs and vertebrae (bone mineral
density was decreased on average by ˜90 mg/mL in the cortical vertebrae in one
strain) and cortical bone in the calvariae (bone mineral density was decreased
on average by ˜60 mg/mL in one strain). Mechanical testing of the femurs
demonstrated that loss of bone in the mice with hypercholesterolemia caused
changes in the mechanical properties of the bone including loss of failure load
(failure load was decreased by ˜10 N in one strain) and energy to failure.
Serologic and histomorphologic analyses suggested that hypercholesterolemia
promotes osteoclastogenesis. These studies support a role for
hypercholesterolemia in the development of osteoporosis and provide a model with
which to test intervention strategies to reduce the effects of
hypercholesterolemia on bone health
Status Completed
Public Release 3/17/2011
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagExperiment / ControlAnimal CountExperiment Description
Data Analysis
TypeCount
Animals54
Experimental Conditions1
Catalog Items3
Curation Info (# flags)3
Phenotype Assays7
Phenotype Measurements213
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
34
0
C57BL/6 scid
0
20
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Experimental Group
Experimental Factor Values


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