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Experiment

Hyperinsulinemic Hyperglycemic clamp order #22096 March 2017
Summary Data Summary
Investigator Chen, Shuai
Description Previous studies with culture cells have suggested that RalGAP complex is
important for glucose homeostasis. However, its in vivo function has not been
studied so far. These two mouse models are the first two models for studying the
in vivo function of this RalGAP complex. Elucidation of its role in glucose
homeostasis will help to understand its relationship with the pathogenesis of
type 2 diabetes.

RalGAPalpha1 is affected in GARNL-KI mice, and RalGAPbeta is affected in
RalGAPbeta KO mice.

Applicable research area(s): Diabetes, Metabolism, Obesity
Status Completed
Public Release 10/20/2022
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal Count
Data Analysis
TypeCount
Animals35
Experimental Conditions5
Catalog Items3
Curation Info (# flags)1
Phenotype Assays19
Phenotype Measurements9878
Histology Images0
Publications0
Phenotypes14


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
20
0
C57BL/6-Ralgapa1tm1.1Schen
0
9
0
C57BL/6-Ralgapbtm1a(KOMP)Wtsi
0
6
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet PicoLab Rodent Diet 5LOD
Crude Protein 23%, crude fat 4.5%, crude fiber 6.0%. Ingredients: dehulled soybean meal, ground corn, dried beet pulp, fish meal, ground oats, dehydrated alfalfa meal, cane molasses, brewers dried yeast, wheat germ, whey, porcine animal fat...
Experimental Factor Values


No documents found.


Mammalian Phenotype (MP) Terms
MPTermIDMPTermNameDefinitionOther Results
MP:0000208decreased hematocrit
less than the average percentage of a volume of a blood sample occupied by red blood cells [MESH:E01.450.375.400]
MMPC Search Results
MP:0001260increased body weight
greater than normal average weight [J:33400]
MMPC Search Results
MP:0001262decreased body weight
lower than normal average weight [PMID:10709991]
MMPC Search Results
MP:0003926decreased cellular glucose uptake
reduced ability of a cell to take in glucose from the environment [RGD:cur]
MMPC Search Results
MP:0003927increased cellular glucose import
increased ability of a cell to take in glucose from the environment [RGD:cur]
MMPC Search Results
MP:0005559increased circulating glucose level
greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source [MGI:cwg| RGD:cur]
MMPC Search Results
MP:0005560decreased circulating glucose level
less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source [MGI:cwg| RGD:cur]
MMPC Search Results
MP:0013278decreased fasting circulating glucose level
reduction in the amount of glucose in the blood at some defined time point after eating compared to controls [MGI:Armida_Di_Fenza]
MMPC Search Results
MP:0013279increased fasting circulating glucose level
increase in the amount of glucose in the blood at some defined time point after eating compared to controls [MGI:Armida_Di_Fenza]
MMPC Search Results
MP:0030016increased adipocyte glucose uptake
increased ability of adipocytes to take in glucose [MGI:anna]
MMPC Search Results
MP:0030017decreased adipocyte glucose uptake
reduced ability of adipocytes to take in glucose [MGI:anna]
MMPC Search Results
MP:0030020decreased cardiac cell glucose uptake
reduced ability of the cells of the heart to take in glucose [MGI:anna]
MMPC Search Results
MP:0030021increased muscle cell glucose uptake
increased ability of muscle cells to take in glucose [MGI:anna]
MMPC Search Results
MP:0030022decreased muscle cell glucose uptake
reduced ability of muscle cells to take in glucose [MGI:anna]
MMPC Search Results

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