| Create Account | login

login

Experiment

Liver lipid levels in Nefh-PRR KO mice fed HFD

Summary

Data Summary

Investigator	Feng, Yumei
Description	This strain models neuronal knockdown of the prorenin receptor in the mouse. 3 month old Mice were fed HFD/NFD for 16 weeks with ad libitum access to food and water. Mice were sacced with isofluorane and CD and tissues were removed and fresh frozen. The project seeks to understand the effect of neuron-specific deletion of secreted prorenin in the brain on the progression of metabolic syndrome, in this case the development of NAFLD. Applicable research area(s): Cardiovascular, Diabetes, Metabolism, Neurobiology, Obesity
Status	Completed
Public Release	12/1/2019
Animal Age	Measured In: week(s) post-natal (w)
Flags

Data Analysis

DOWNLOAD ALL DATA (.csv)

Type	Count
Animals	17
Experimental Conditions	5
Catalog Items	1
Curation Info (# flags)	1
Phenotype Assays	2
Phenotype Measurements	34
Histology Images	0
Publications	0

Animals

Strain Name	Common Name	Females	Males	Unknown
C57BL/6-Atp6ap2^tm1.1Aich Tg(Nefh-cre)12Kul	Nefh-PRRKO	0	7	0
B6.FVB-Atp6ap2^tm1.1Aich/Y	B6.FVB-Atp6ap2^tm1.1Aich/Y	3	7	0

Animals/Strains

Experimental Factors

	Categorical Values
	Name / Abbreviation	Description
	Experimental Factor: Experimental Group
	Control	This animal belongs to the control group for the experiment.
	Experiment	This animal belongs to experimental group that is homozygous for gene manipulations.
	Experimental Factor: Feeding Group
	Fed	Animals are allowed to have food.
	Experimental Factor: Mouse Diet
	Research Diets - D12450J	Rodent Diet with 10% fat, 70% carbohydrate, 20% protein
	Research Diets - D12492	Rodent Diet with 34% Fat, 60% kcal from Fat
	Experimental Factor: Tissue Source
	liver	liver

Experimental Factor (Units)
Experimental Group
Fast Duration (hr)
Feeding Group
Mouse Diet
Tissue Source

Experimental Factor Values

Phenotype Assays Add / Edit

Name	Abbreviation
cholesterol, tissue	cholesterol (tissue)
triglycerides, tissue	TG (tissue)

No documents found.

Back to Top

Store Credentials?

MMPC-Live web resource – Terms of Use

Warranty disclaimer and copyright notice

THE MMPC-Live MAKES NO REPRESENTATION ABOUT THE SUITABILITY OR ACCURACY OF THE SOFTWARE OR DATA FOR ANY PURPOSE, AND MAKES NO WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR THAT THE USE OF THE SOFTWARE OR DATA WILL NOT INFRINGE ANY THIRD PARTY PATENTS, COPYRIGHTS, TRADEMARKS, OR OTHER RIGHTS. THE SOFTWARE AND DATA ARE PROVIDED "AS IS".

The Mouse Metabolic Phenotyping Centers (MMPC-Live) is an NIDDK funded consortium and adheres to the NIH Data Sharing Policy.

MMPC-Live clients make their data freely available whereby MMPC-Live users may freely build upon, enhance and reuse those data for any purpose without restriction. Scholarly citation norms must be followed for content reuse. Please acknowledge the MMPC-Live using the following text: 'The MMPC-Live data used in this manuscript was supported by the NIDDK National Mouse Metabolic Phenotyping Centers (MMPC-Live, RRID:SCR_008997, www.mmpc.org)'. To cite specific MMPC-Live centers, please use the appropriate RRID available from the MMPC-Live website (https://www.mmpc.org/shared/centers.aspx).

Please note that the acknowledgment text includes a Research Resource Identifier (RRID) for the MMPC-Live CU and Centers. Reproducibility is one of the corner stones of effective, open and transparent biomedical published research. However, too often, resources (e.g. model organisms, antibodies, and tools) are not reported with adequate detail to ensure others can replicate or expand upon the published results. The Research Resource Identification Initiative (#RII) seeks to change these limitations in reporting by the use of unique Research Resource Identifiers (RRIDs). This initiative is designed to encourage authors to provide identification of the types of resources used in their research by adding a globally unique accession number to the resources described in the their manuscripts. These identifiers, called RRIDs, will allow authors to cite the resources that they use in their manuscripts. RRIDs allow for easy tracking of all papers that have used the same resource making it easy to access how the same resources works in other scenarios.

It is expected that MMPC-Live users follow scholarly citation norms, giving credit to fellow scholars when accessing/using protocols and data, including data derived by MMPC-Live (such as summary data) and any plots, tables or screenshots depicting those data.

It is possible for invalid or incomplete results to be presented on the MMPC-Live web site due to software bugs, data problems, or artifacts of human error. Data sets are not necessarily static; we reserve the right to post corrections and updates as needed.

Prohibited use. Data contributors and data users may not use MMPC-Live in any unlawful manner, or in any manner that could impair MMPC-Live services, security or functionality. Automated usage (webcrawlers and similar) must observe each page's "meta robots" html tags and space requests by ≥ 2 seconds. We reserve the right to block any IP associated with what we consider to be excessive or abusive usage patterns, and/or to take any action we deem necessary.

MMPC-Live is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice.

Menu

Home

Contact

About MMPC

Animal Husbandry

Tests Data

Search Data

Analysis

Clients

MMPC Centers

Newsletter

Interested in receiving MMPC News?

Mouse Phenotyping
@NationalMMPC

2017 National MMPC. All Rights Reserved.