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Experiment

Liver lipid levels in Nefh-PRR KO mice fed HFD
Summary Data Summary
Investigator Feng, Yumei
Description This strain models neuronal knockdown of the prorenin receptor in the mouse. 3
month old Mice were fed HFD/NFD for 16 weeks with ad libitum access to food and
water. Mice were sacced with isofluorane and CD and tissues were removed and
fresh frozen. The project seeks to understand the effect of neuron-specific
deletion of secreted prorenin in the brain on the progression of metabolic
syndrome, in this case the development of NAFLD.

Applicable research area(s): Cardiovascular, Diabetes, Metabolism, Neurobiology,
Obesity
Status Completed
Public Release 12/1/2019
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals17
Experimental Conditions5
Catalog Items1
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements34
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
Nefh-PRRKO
0
7
0
B6.FVB-Atp6ap2tm1.1Aich/Y
3
7
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Fast Duration (hr)

 fast duration
Length of time the animal was fasted

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Research Diets - D12450J
Rodent Diet with 10% fat, 70% carbohydrate, 20% protein
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat

Experimental Factor: Tissue Source

 liver
liver


Phenotype Assays Add / Edit


No documents found.

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