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Experiment

Metabolic Clamp Study to Assess Insulin Sensitivity in HFD-Fed Adipose-Smarca4
KO Mice

Summary

Data Summary

Investigator	Sun, Ai-jun
Description	The purpose of this experiment is to explore the role of Brg1 (aka Smarca4) in obesity-induced insulin resistance. To accomplish this, Smarca4 is knocked out in white adipose tissue (WAT) and brown adipose tissue (BAT) using the Cre recombinase, Adipoq-Cre.
Status	Completed
Public Release	9/6/2020
Animal Age	Measured In: week(s) post-natal (w)
Flags

Data Analysis

DOWNLOAD ALL DATA (.csv)

Type	Count
Animals	24
Experimental Conditions	2
Catalog Items	6
Curation Info (# flags)	0
Phenotype Assays	14
Phenotype Measurements	336
Histology Images	0
Publications	0

Animals

Strain Name	Common Name	Females	Males	Unknown
STOCK Smarca4^tm1.1Grc/J	STOCK Smarca4^tm1.1Grc/J	0	12	0
STOCK Smarca4^tm1.1Grc Tg(Adipoq-cre)1Evdr/J	STOCK Smarca4^tm1.1GrcTg(Adipoq-cre)1Evdr/J	0	12	0

Animals/Strains

Experimental Factors

	Categorical Values
	Name / Abbreviation	Description
	Experimental Factor: Experimental Group
	Control	This animal belongs to the control group for the experiment.
	Experiment	This animal belongs to experimental group that is homozygous for gene manipulations.
	Experimental Factor: Mouse Diet
	Research Diets - D12450B	Research Diets - D12450B Rodent Diet with 10% kcal% fat.
	Research Diets - D12492	Rodent Diet with 34% Fat, 60% kcal from Fat

Experimental Factor (Units)
Experimental Group
Mouse Diet

Experimental Factor Values

Phenotype Assays Add / Edit

Name	Abbreviation
body mass	W rodent
fat body mass	fat body mass
lean body mass	lean body mass
glucose infusion rates	glucose infusion rates
glucose, basal	glucose, basal
hepatic glucose production, basal	hepatic glucose production, basal
glucose turnover, whole body	glucose turnover, whole body
glycogen/lipid synthesis, whole body	glycogen/lipid synthesis, whole body
glycolysis, whole body	glycolysis, whole body
glucose, clamp average	glucose, clamp average
Hepatic Glucose Production, clamp	Hepatic Glucose Production, clamp
glucose uptake, muscle	glucose uptake muscl
glucose uptake, white adipose	glucose uptake white
hepatic insulin action	HIA

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