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Experiment

Analytical Study in NOD/ShiLtJ or STAT5 A/B KO mice
Summary Data Summary
Investigator Coschigano, Karen
Description We are investigating the mechanisms of acute and chronic kidney injury in STAT5
KO mice after treatment with cisplatin or STZ as well as in NOD mice challenged
with coxsackie virus.

Applicable research area(s): Diabetes, Genitourinary
Status Completed
Public Release 9/20/2020
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainExperiment Description
Data Analysis
TypeCount
Animals135
Experimental Conditions11
Catalog Items2
Curation Info (# flags)2
Phenotype Assays2
Phenotype Measurements155
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
NOD
113
0
0
Stat5a/Stat5b DKO
0
22
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Cisplatin
chemotherapy medication used to treat a number of cancers
 No Drug/Treatment
No Drug or Treatment done on these samples
 Saline
Saline
 STZ
Streptozotocin (STZ) is an alkylating agent that targets insulin-producing beta cells in the pancreas, mimicking Type 1 diabetes phenotypes in mice.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 IP
The drug was delivered intraperitoneal.

Experimental Factor: Drug Dose (AU)

 Drug Dose
A numerical value indicating the dose of a drug administered. The unit of measure is indicated in the Drug Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Drug Dose Units

 mg/kg
milligrams per kilogram

Experimental Factor: Drug Treatment Duration (day)

 Drug Treatment Durat
Indicates the number of days an animal has been on a drug treatment regimen.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Time Since Drug Administered (day)

 Time Since Drug Admi
The time, in days, since the drug was given to the subject.

Experimental Factor: Time Since Virus Administered (day)

 Time Since Virus Adm
The time, in days, since the virus was given to the subject.

Experimental Factor: Viral Dose (AU)

 Viral Dose
A numerical value indicating the dose of a virus administered. The unit of measure is indicated in the Viral Dose Units categorical value that accompanies this experimental condition.

Experimental Factor: Viral Dose Units

 PFU
plaque forming units

Experimental Factor: Virus Injected

 Coxsackie B4
Coxsackie B4 has a cell tropism for natural killer cells and pancreatic islet cells
 None
No virus was injected.
 Vehicle
Injection of vehicle without virus. Negative control.


Phenotype Assays Add / Edit



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