mmpc-logo mmpc-logo
twitter-logo @NationalMMPC
| Create Account | login
Experiment

Influence of brown adipose specific CFTR KO on energy expenditure at various
environmental temperatures in male mice
Summary Data Summary
Investigator Yoon, John
Description To determine whether brown adipose tissue specific inactivation of CFTR alters
energy expenditure assessed at several different temperatures (male mice are
used).
Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial
chloride ion transporter whose mutation causes cystic fibrosis and depending
upon the mutation results in a wide spectrum of disease severity. Interestingly,
a gastrointestinal malabsorption of lipids and a disturbance in plasma and
tissue fatty acid (FA) profile are additional feature of cystic fibrosis. This
study will determine whether brown adipose tissue specific inactivation of CFTR
alters energy expenditure assessed at several different temperatures (30, 22,
and 10°C) or body composition (DEXA) in male mice
Status Completed
Public Release 3/21/2022
Animal Age Measured In: week(s) post-natal (w)
Data Analysis
TypeCount
Animals18
Experimental Conditions2
Catalog Items3
Curation Info (# flags)0
Phenotype Assays31
Phenotype Measurements1674
Histology Images0
Publications0
Phenotypes2


Animals
Strain NameCommon NameFemalesMalesUnknown
CFTR-UCP1 CRE
0
9
0
Cftrfl10; B6.Cg-Cftrtm1Cwr
0
9
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.


No documents found.

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.