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New comment to be added:
Influence of brown adipose specific CFTR KO on energy expenditure at various
environmental temperatures in male mice
To determine whether brown adipose tissue specific inactivation of CFTR alters
energy expenditure assessed at several different temperatures (male mice are
Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial
chloride ion transporter whose mutation causes cystic fibrosis and depending
upon the mutation results in a wide spectrum of disease severity. Interestingly,
a gastrointestinal malabsorption of lipids and a disturbance in plasma and
tissue fatty acid (FA) profile are additional feature of cystic fibrosis. This
study will determine whether brown adipose tissue specific inactivation of CFTR
alters energy expenditure assessed at several different temperatures (30, 22,
and 10°C) or body composition (DEXA) in male mice
week(s) post-natal (w)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Environmental Temperature (°C)
The temperature of the environment when the measurement was taken.
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Environmental Temperature (°C) (°C)
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oxygen consumption (Light Period)
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
bone mineral density
bone mineral content
fat tissue, %
% body fat
heat (Light Period)
oxygen consumption (Dark Period)
carbon dioxide production Light Period
carbon dioxide production Dark Period
respiratory exchange ratio (Dark Period)
heat (Dark Period)
carbon dioxide production
respiratory exchange ratio
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (avg 24 hr)
energy intake avg 24
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
total tissue mass
heat - 24h
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Mammalian Phenotype (MP) Terms
decreased percent body fat/body weight
less fat| relative to controls| expressed as a percentage of total body weight [MGI:cwg]
MMPC Search Results
decreased total body fat amount
less than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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