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Experiment

Influence of brown adipose specific CFTR KO on energy expenditure at various
environmental temperatures in male mice
Summary Data Summary
Investigator Yoon, John
Description To determine whether brown adipose tissue specific inactivation of CFTR alters
energy expenditure assessed at several different temperatures (male mice are
used).
Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial
chloride ion transporter whose mutation causes cystic fibrosis and depending
upon the mutation results in a wide spectrum of disease severity. Interestingly,
a gastrointestinal malabsorption of lipids and a disturbance in plasma and
tissue fatty acid (FA) profile are additional feature of cystic fibrosis. This
study will determine whether brown adipose tissue specific inactivation of CFTR
alters energy expenditure assessed at several different temperatures (30, 22,
and 10°C) or body composition (DEXA) in male mice
Status Completed
Public Release 3/21/2022
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flag
Data Analysis
TypeCount
Animals18
Experimental Conditions2
Catalog Items3
Curation Info (# flags)0
Phenotype Assays31
Phenotype Measurements1674
Histology Images0
Publications0
Phenotypes2


Animals
Strain NameCommon NameFemalesMalesUnknown
CFTR-UCP1 CRE
0
9
0
Cftrfl10; B6.Cg-Cftrtm1Cwr
0
9
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor Values


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