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Experiment

Hyperinsulinemic clamp order #30460 Nov 2020
Summary Data Summary
Investigator jain, shanu
Description Liver is an essential organ regulating whole body carbohydrate and lipid
metabolism. Normal liver function is essential to maintain blood glucose levels
and supply of energy source to other body organs. Dysregulation of liver
function can result in development of liver disorders such as fatty liver that
can be a risk factor for the development of other metabolic disorders. Excessive
glucose output from liver can increase blood glucose levels causing the
development of type 2 diabetes. Therefore, it is essential to understand the
mechanisms that regulate liver metabolism. In this study, we aim to understand
the role of A1AR in the hepatocytes glucose metabolism. This study will help us
to target A1AR for therapeutic treatment of liver disorders.
Status Completed
Public Release 2/25/2023
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal Count
Data Analysis
TypeCount
Animals22
Experimental Conditions5
Catalog Items4
Curation Info (# flags)1
Phenotype Assays6
Phenotype Measurements900
Histology Images0
Publications0
Phenotypes1


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
11
0
C57BL/6-Adora1tm1GreTg(CMV-HBV-Cre)
0
11
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 BioServ F3282
Rodent Hig Fat Diet. Protein 20.%, Fat 35.5%, Fiber 0.0%, Ash 3.2%, Moisture <5.0%, Carbohydrate 36.3%. Ingredients: Lard, Casein, Dextrose, Sucrose, DL-Methionine, Choline Chloride, Vitamin Mix and Mineral Mix
Experimental Factor Values


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