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Experiment

Circulating inflammatory marker levels in B6 mice treated with letrozole
Summary Data Summary
Investigator Thackray, Varykina
Description Determine if letrozole treatment results in changes in circulating cytokine
levels (TNFa, IL1b, INFg, IL6, IL10 and IL22).
Status Completed
Public Release 6/21/2023
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainAnimal CountMouse Diet
Data Analysis
TypeCount
Animals35
Experimental Conditions9
Catalog Items2
Curation Info (# flags)3
Phenotype Assays6
Phenotype Measurements210
Histology Images0
Publications0
Phenotypes4


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
35
0
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Letrozole
Letrozole (INN, trade name Femara) is an oral non-steroidal aromatase inhibitor for the treatment of hormonally-responsive breast cancer after surgery. These are continuous release pellets.
 Vehicle
Vehicle - Control

Experimental Factor: Drug Delivery Route

 SC
The drug was delivered subcutaneously.

Experimental Factor: Drug Dose Units

 µg/day
micrograms per day

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fed
Animals are allowed to have food.

Experimental Factor: Mouse Diet

 Teklad - 7004
Rodent diet with 29% kcal fat, 51% kcal carbohydrate, 20% kcal protein
 Teklad-130852
Custom diet (17.7% protein; 60.1% carbohydrate; 7.2% fat) irradiated

Experimental Factor: Tissue Source

 serum
serum
Experimental Factor Values


No documents found.


Mammalian Phenotype (MP) Terms
MPTermIDMPTermNameDefinitionOther Results
MP:0008553increased circulating tumor necrosis factor level
greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses| particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium [ISBN:0-8153-1691-7| MESH:D12.644.276.374.500.800]
MMPC Search Results
MP:0008560increased tumor necrosis factor secretion
increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses| particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium [ISBN:0-8153-1691-7| MESH:D12.644.276.374.500.800]
MMPC Search Results
MP:0008593increased circulating interleukin-10 level
increase in the amount in the blood of a cytokine produced by a variety of cell types| including T-cells| monocytes| dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation [MESH:D12.644.276.374.465.510]
MMPC Search Results
MP:0008660increased interleukin-10 secretion
increase in the production or release of a cytokine produced by a variety of cell types| including T-cells| monocytes| dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation [MESH:D12.644.276.374.465.510]
MMPC Search Results

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