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Experiment

2021-01-19 Myers-Alison 8 mice Insulin Clamp
Summary Data Summary
Investigator Affinati, Alison
Description Leptin receptor mediates the effect of leptin on body weight and blood glucose.
This model allows up to manipulate LepR neuron activity specifically within the
VMN, which is associated with glucose and body weight regulation.
Status Completed
Public Release 12/17/2023
Animal Age Measured In: month(s) post-natal (m)
Flags has-data-flagSame StrainMetadataNeed Conditions
Data Analysis
TypeCount
Animals8
Experimental Conditions4
Catalog Items1
Curation Info (# flags)3
Phenotype Assays3
Phenotype Measurements336
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
B6.129-Leprtm3(cre)Mgmj/J
3
5
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Clozapine N-oxide
Inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Virus Injected

 AAV-GFP
Adeno associated virus with over expressing green fluorescent protein (GFP)
 Vehicle
Injection of vehicle without virus. Negative control.
Experimental Factor Values


No documents found.

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