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Experiment

2019-07-21 Olson - Ian 16 Mice NMR
Summary Data Summary
Investigator Olson, David
Description We are investigating the role of CalcR-PVH neurons in regulating food intake and
energy expenditure through the use of DREADDs technology. This will aid in our
understanding of how the subpopulations of the PVH influence energy balance
differently.
Status Completed
Public Release 3/15/2024
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagExperiment / Control
Data Analysis
TypeCount
Animals16
Experimental Conditions5
Catalog Items1
Curation Info (# flags)1
Phenotype Assays6
Phenotype Measurements192
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
Calcrcre
0
16
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 Clozapine N-oxide
Inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its

Experimental Factor: Experimental Group

 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet PicoLab Rodent Diet 5LOD
Crude Protein 23%, crude fat 4.5%, crude fiber 6.0%. Ingredients: dehulled soybean meal, ground corn, dried beet pulp, fish meal, ground oats, dehydrated alfalfa meal, cane molasses, brewers dried yeast, wheat germ, whey, porcine animal fat...

Experimental Factor: Second Drug Administered

 Saline
The second drug that was administered during the study.
Experimental Factor Values


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