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Experiment

2018-01-04 Olson - Ian 12 Mice NMR
Summary Data Summary
Investigator Olson, David
Description We are investigating a subpopulation of PVH neurons for their role in energy
homeostasis. This may translate to human neurophysiology.
Status Completed
Public Release 6/17/2024
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals13
Experimental Conditions4
Catalog Items1
Curation Info (# flags)1
Phenotype Assays6
Phenotype Measurements156
Histology Images0
Publications0


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
4
0
IRS-4 KO
0
9
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 LabDiet PicoLab Rodent Diet 5LOD
Crude Protein 23%, crude fat 4.5%, crude fiber 6.0%. Ingredients: dehulled soybean meal, ground corn, dried beet pulp, fish meal, ground oats, dehydrated alfalfa meal, cane molasses, brewers dried yeast, wheat germ, whey, porcine animal fat...

Experimental Factor: Virus Injected

 AAV-Flex-hM3Dq
A modified human muscarinic receptor coupled to the stimulatory Gq-protein which activates neurons upon binding the synthetic ligand clozapine N-oxide. Cre-dependent AAV-Flex-hM3Dq-mCherry (AAV-Flex-hM3Dq, titer: 4 × 1012 virus molecules/mL, purchased fro
 AAV-Flex-TetTox
Tetanus toxin cleaves synaptobrevin, a component of the SNARE core and prevents release of synaptic vesicles from targeted neurons.
Experimental Factor Values


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