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Strain
B6.129-Irs4tm1Lhd/J

Summary Data Summary
Official Name B6.129-Irs4tm1Lhd/J
Common Name IRS-4 KO
Description These Irs4 knock-out mice exhibit impaired glucose tolerance
and slight retardation in growth rate.
Development Status Characterizing multiple lines
Creation Method chemical induced
Phenotype Description Mice homozygous for the Irs4tm1Lhd targeted mutation are
viable and fertile. However, homozygous mutant mice do
appear to be at a greater risk of perinatal lethality and
tend to produce fewer litters. At birth, surviving mice
appear normal in size and do not display any gross physical
or behavioral abnormalities. RT-PCR fails to detect Irs4
mRNA in any tissues analyzed. Growth rate appears to be
slightly retarded beginning 6 weeks of age (males about 10%
lighter). Homozygotes also exhibit impaired glucose
tolerance and have slightly lower blood glucose levels when
compared to wild-type mice. These phenotypes are more
pronounced in males than in females.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 5


Investigators
NameInstitution
David OlsonUniversity of Michigan-Ann Arbor


Genomic Information
GeneAllele 1Allele 2Protocol
Irs4knockoutknockoutNot Specified


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