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New comment to be added:
Gross body composition and Energy Expenditure in PWS (Snord116del) mice
Prader–Willi syndrome (PWS), a genetic disorder of obesity, intellectual
disability and sleep abnormalities, is caused by loss of non-coding RNAs on
paternal chromosome 15q11-q13. The imprinted minimal PWS locus encompasses a
long non-coding RNA (lncRNA) transcript processed into multiple SNORD116 small
nucleolar RNAs and the spliced exons of the host gene, 116HG. Mice with an
engineered deletion of the Snord116 repeat cluster (Snord116del) recapitulate
the PWS phenotype of altered metabolism and growth deficiency, although not
obesity. In mice, the Snord116/116HG transcript is expressed only in neurons,
suggesting that the metabolic phenotype is due to the central dysregulation of
energy use in the central nervous system. We wish to examine energy expenditure
and RER in Snord116del mice.
day(s) post-natal (d)
DOWNLOAD ALL DATA (.csv)
Curation Info (# flags)
one of [Control, Control-Het, ...]
one of [3mAIN76(HF0.18), 3mAIN76(HF0.18)early, ...]
Add / Edit
energy intake (24 hr)
energy intake (24 hr)
oxygen consumption (Light Period)
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
bone mineral density
bone mineral content
fat tissue, %
% body fat
heat (Light Period)
oxygen consumption (Dark Period)
carbon dioxide production Light Period
carbon dioxide production Dark Period
respiratory exchange ratio (Dark Period)
heat (Dark Period)
carbon dioxide production
respiratory exchange ratio
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
total tissue mass
heat - 24h
A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure.
Powell WT, Coulson RL, Crary FK, Wong SS, Ach RA, Tsang P, Alice Yamada N, Yasui DH, Lasalle JM
Human molecular genetics
, 2013 (22), 4318 - 4328
Experiment: Gross body composition and Energy Expenditure in PWS (Snord116del) mice; Type: Data
3234_Yasui_DEXA data 040212.xlsx
YASUI Data Report EE Activity RER 7-25-12.pdf
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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