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Experiment

Gross body composition and Energy Expenditure in PWS (Snord116del) mice (cohort
2)
Summary Data Summary
Investigator Yasui, Dag
Description Prader–Willi syndrome (PWS), a genetic disorder of obesity, intellectual
disability and sleep abnormalities, is caused by loss of non-coding RNAs on
paternal chromosome 15q11-q13. The imprinted minimal PWS locus encompasses a
long non-coding RNA (lncRNA) transcript processed into multiple SNORD116 small
nucleolar RNAs and the spliced exons of the host gene, 116HG. Mice with an
engineered deletion of the Snord116 repeat cluster (Snord116del) recapitulate
the PWS phenotype of altered metabolism and growth deficiency, although not
obesity. In mice, the Snord116/116HG transcript is expressed only in neurons,
suggesting that the metabolic phenotype is due to the central dysregulation of
energy use in the central nervous system. We wish to examine energy expenditure
and RER in Snord116del mice.
Status Completed
Public Release 2/14/2015
Animal Age Measured In: day(s) post-natal (d)
Data Analysis
TypeCount
Animals16
Experimental Conditions2
Catalog Items1
Curation Info (# flags)0
Phenotype Assays31
Phenotype Measurements496
Histology Images0
Publications1
Documents2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
4
0
paternal Snord116del -/+
0
12
0


Experimental Factors
 Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.

Experimental Factor: Mouse Diet

 LabDiet 5058
PicoLab Mouse Diet 20, 20.0% protein (Calories: 23% protein, 22% Fat, 55% Carbohydrate)


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