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Experiment

Circulating HDL-C and LDL-C levels in NCoR mice
Summary Data Summary
Investigator Privalsky, Martin
Description Mice were fed either high fat (HFD, 60%KCal–Research Diets D12492) or low fat
(LFD, 10%KCal–Research Diets D12450B) diet for 12weeks. Mice were fasted 6-8
hours before collecting serum

Genotype of KO mice is NCoR1omega-/- (meaning it does not express the longer
NCoR1 omega alternatively spliced isoform, but instead expresses entirely the
shorter NCoR1d isoform). This strain displays enhanced obesity, adiposity, and
hepatosteatosis when challenged with a high fat diet. Curiously the mice remain
insulin sensitive and glucose tolerant, unlike wild type C57BL/6 mice.

Applicable Research Area(s): Diabetes, Obesity, Metabolism
Status Completed
Public Release 2/18/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flag
Data Analysis
TypeCount
Animals16
Experimental Conditions5
Catalog Items2
Curation Info (# flags)0
Phenotype Assays2
Phenotype Measurements32
Histology Images0
Publications0
Phenotypes2


Animals
Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
9
0
NCoR delta
0
7
0

Animals/Strains
Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Feeding Group

 Fasted
Animals are deprived of food but not water.

Experimental Factor: Mouse Diet

 Research Diets - D12450B
Research Diets - D12450B Rodent Diet with 10% kcal% fat.
 Research Diets - D12492
Rodent Diet with 34% Fat, 60% kcal from Fat

Experimental Factor: Tissue Source

 serum
serum
Experimental Factor Values


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