mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Strain
B6.129S4-Ncor1tm1.1Anh

Summary Data Summary
Official Name B6.129S4-Ncor1tm1.1Anh
Common Name NCoR delta
Description NCoR-omega and NCoR-delta share a splice acceptor but
utilize two distinct splice donors. Splice-specific NCoR
knockout mice were generated by the Mouse Biology Program at
the University of California at Davis (UC Davis). The
NCoR-omega splice donor was inactivated by site-directed
mutagenesis in mice without disrupting the NCoR-delta splice
donor or the NCoR-delta protein sequence to generate
NCoR-omega -/- mice.

A loxP site was inserted upstream of exon 38 and an FRT
flanked neomycin resistance cassette with a 5' loxP site was
inserted downstream of exon 41. Flp-mediated recombination
removed the selection cassette and left exons 38 through 41
floxed. Cre-mediated recombination removed exons 38 through
41, encoding two of the three receptor interacting domains
(N2 and N3).
Development Status Phenotyping ongoing
Creation Method congenic
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 5


Investigators
NameInstitution
Martin PrivalskyUniversity of California Davis


Genomic Information
GeneAllele 1Allele 2Protocol
Ncor1knockoutknockoutNot Specified


Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.