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Experiment

Effect of PI3K inhibitor PX866 and over-expression of sortilin 1 on plasma
lipoprotein profiles in WT / MTLKUMC0914B
Summary Data Summary
Investigator Li, Tiangang
Description We want to test the effect of PI3K inhibitor PX866 and over-expression of
sortilin 1 on the plasma lipoprotein profiles in wild type mice

PI3K inhibitor increase total plasma cholesterol

Plasma lipoprotein separation and cholesterol analysis of WT mice given PI3K
inhibitor PX866.
Status Completed
Public Release 2/27/2017
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainExperiment Description
Data Analysis
TypeCount
Animals4
Experimental Conditions2
Catalog Items3
Curation Info (# flags)2
Phenotype Assays8
Phenotype Measurements32
Histology Images0
Publications0


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
4
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Drug Administered

 AdSort1
Over-expression of sortilin 1 protein
 AdSort1+PX866
Both PI3K inhibitor (medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes) and over-expression of sortilin 1 protein.
 PX866
PI3K inhibitor - medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes
 Vehicle
Vehicle - Control

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.
Experimental Factor (Units)
Drug Administered
Experimental Group



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