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Publication
Adropin deficiency is associated with increased adiposity and insulin
resistance.
Authors Ganesh Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD,
Mynatt RL, Butler AA
Submitted By Andrew Butler on 9/18/2012
Status Published
Journal Obesity (Silver Spring, Md.)
Year 2012
Date Published
Volume : Pages 20 : 1394 - 1402
PubMed Reference 22318315
Abstract Adropin is a secreted peptide that improves hepatic steatosis and glucose
homeostasis when administered to diet-induced obese mice. It is not clear if
adropin is a peptide hormone regulated by signals of metabolic state. Moreover,
the significance of a decline in adropin expression with obesity with respect to
metabolic disease is also not clear. We investigated the regulation of serum
adropin by metabolic status and diet. Serum adropin levels were high in chow-fed
conditions and were suppressed by fasting and diet-induced obesity (DIO). High
adropin levels were observed in mice fed a high-fat low carbohydrate diet,
whereas lower levels were observed in mice fed a low-fat high carbohydrate diet.
To investigate the role of adropin deficiency in metabolic homeostasis, we
generated adropin knockout mice (AdrKO) on the C57BL/6J background. AdrKO
displayed a 50%-increase in increase in adiposity, although food intake and
energy expenditure were normal. AdrKO also exhibited dyslipidemia and impaired
suppression of endogenous glucose production (EndoR(a)) in
hyperinsulinemic-euglycemic clamp conditions, suggesting insulin resistance.
While homo- and heterozygous carriers of the null adropin allele exhibited
normal DIO relative to controls, impaired glucose tolerance associated with
weight gain was more severe in both groups. In summary, adropin is a peptide
hormone regulated by fasting and feeding. In fed conditions, adropin levels are
regulated dietary macronutrients, and increase with dietary fat content. Adropin
is not required for regulating food intake, however, its functions impact on
adiposity and are involved in preventing insulin resistance, dyslipidemia, and
impaired glucose tolerance.




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