mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism.
Authors Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero Calderon P, Zhang L,
Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J,
Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar SM
Submitted By Saptarsi Haldar on 2/24/2014
Status Published
Journal The Journal of biological chemistry
Year 2014
Date Published
Volume : Pages 289 : 5914 - 5924
PubMed Reference 24407292
Abstract The mammalian heart, the bodys largest energy consumer, has evolved robust
mechanisms to tightly couple fuel supply with energy demand across a wide range
of physiologic and pathophysiologic states. Yet, when compared to other organs,
relatively little is known about the molecular machinery that directly governs
metabolic plasticity in the heart. While previous studies have defined Kruppel
like Factor 15 (KLF15) as a transcriptional repressor of path-ologic cardiac
hypertrophy, a direct role for the KLF family in cardiac metabolism has not been
previously established. We show in human heart samples that KLF15 is induced
after birth and reduced in heart failure, a myocardial expression pattern that
parallels reliance on lipid oxidation. Isolated working heart studies and
unbiased transcriptomic profiling in Klf15 deficient hearts demonstrate that
KLF15 is an essential regulator of lipid flux and metabolic homeostasis in the
adult myocardium. An important mechanism by which KLF15 regulates its direct
transcriptional targets is via interaction with p300 and recruitment of this
critical co activator to promoters. This study establishes KLF15 as a key
regulator of myocardial lipid utilization and is the first to implicate the KLF
transcription factor family in cardiac metabo-lism.




Strains


Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.