mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Strain
C57BL/6J-Klf15tm1Jain

Summary Data Summary
Official Name C57BL/6J-Klf15tm1Jain
Common Name C57BL/6J-Klf15-/-
Description Klf15 KO mice have defects in skeletal and cardiac beta
oxidation in vivo. Klf15 KO mice have reduced capacity for
endurance exercise and isolated skeletal muscle is more
fatiguable. In addition to beta oxidation defects, there may
be defects in fatty acid uptake in vivo as well. There is no
difference in basal energy expenditure as assessed by
indirect calorimetry.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 5
Publications 6


Investigators
NameInstitution
Mukesh JainCase Western Reserve


Genomic Information
GeneAllele 1Allele 2Protocol
Klf15knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Regulation of gluconeogenesis by Krüppel-like factor 15.
Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK
Cell Metabolism, 2007 (5), 305 - 312
17403374
Published
Klf15 orchestrates circadian nitrogen homeostasis.
Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK
Cell Metabolism, 2012 (15), 311 - 323
Submitted Externally
22405069
Published
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.
Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK
Proceedings of the National Academy of Sciences of the United States of America, 2012 (109), 6739 - 6744
Submitted Externally
22493257
Published
KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance.
Jung DY, Chalasani U, Pan N, Friedline RH, Prosdocimo DA, Nam M, Azuma Y, Maganti R, Yu K, Velagapudi A, O'Sullivan-Murphy B, Sartoretto JL, Jain MK, Cooper MP, Urano F, Kim JK, Gray S
PLoS ONE, 2013 (8), e77851
24167585
Published
Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism.
Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar SM
The Journal of biological chemistry, 2014 (289), 5914 - 5924
24407292
Published
Circadian control of bile acid synthesis by a KLF15-Fgf15 axis.
Han S, Han SS, Zhang R, Jain R, Shi H, Zhang L, Zhou G, Sangwung P, Tugal D, Atkins GB, Prosdocimo DA, Lu Y, Han X, Tso P, Liao X, Epstein JA, Jain MK
Nature communications, 2015 (6), 7231 - 7
26040986
Published

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.