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Publication
Cholesteryl ester transfer protein protects against insulin resistance in obese
female mice.
Authors Cappel DA, Palmisano BT, Emfinger CH, Martinez MN, McGuinness OP, Stafford JM
Submitted By Submitted Externally on 10/26/2016
Status Published
Journal Molecular metabolism
Year 2013
Date Published
Volume : Pages 2 : 457 - 67
PubMed Reference 24327961
Abstract Cholesteryl ester transfer protein (CETP) shuttles lipids between lipoproteins,
culminating in cholesteryl ester delivery to liver and increased secretion of
cholesterol as bile. Since gut bile acids promote insulin sensitivity, we aimed
to define if CETP improves insulin sensitivity with high-fat feeding. CETP and
nontransgenic mice of both sexes became obese. Female but not male CETP mice had
increased ileal bile acid levels versus nontransgenic littermates. CETP
expression protected female mice from insulin resistance but had a minimal
effect in males. In liver, female CETP mice showed activation of bile
acid-sensitive pathways including Erk1/2 phosphorylation and Fxr and Shp gene
expression. In muscle, CETP females showed increased glycolysis, increased mRNA
for Dio2, and increased Akt phosphorylation, known effects of bile acid
signaling. These results suggest that CETP can ameliorate insulin resistance
associated with obesity in female mice, an effect that correlates with increased
gut bile acids and known bile-signaling pathways.






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