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Strain
C57BL/6-Tg(CETP)UCTP20Pnu/J

Summary Data Summary
Official Name C57BL/6-Tg(CETP)UCTP20Pnu/J
Common Name C57BL6/J-HuCETP
Description Transgenic mice on a genetic background that involves
C57BL/6J and CBA/J show a marked increase in CETP mRNA in
liver when mice are fed a high fat, high cholesterol diet.
Less dramatic increases are observed in spleen, small
intestine and adipose tissues. Elevated plasma CETP protein
levels are also observed.

The transgene contains the human CETP mini gene under the
control of its own promoter. The mini gene consists of 3.2
Kb of 5' flanking sequence, exons 1-2 and 13-16, and 2.0 Kb
of 3' flanking sequence.
Creation Method transgenic
Background C57BL/6
Breeding Type intercross
Phenotype Description Mice carrying the human CETP minigene under the control of
its own promoter show a marked increase in CETP mRNA in
liver when mice are fed a high fat, high cholesterol diet.
Less dramatic increases are observed in spleen, small
intestine and adipose tissues. Elevated plasma CETP protein
levels are also observed. Mice carrying human CETP show
reduced levels of plasma high density lipoprotein. This
strain has been a useful model in studies related to
cholesterol metabolism.
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 4
Publications 3


Investigators
NameInstitution
John StaffordVanderbilt University


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedNot SpecifiedCETPNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones.
Martinez MN, Emfinger CH, Overton M, Hill S, Ramaswamy TS, Cappel DA, Wu K, Fazio S, McDonald WH, Hachey DL, Tabb DL, Stafford JM
Journal of lipid research, 2012 (53), 379 - 89
Submitted Externally
22215797
Published
Cholesteryl ester transfer protein protects against insulin resistance in obese female mice.
Cappel DA, Palmisano BT, Emfinger CH, Martinez MN, McGuinness OP, Stafford JM
Molecular metabolism, 2013 (2), 457 - 67
Submitted Externally
24327961
Published
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Palmisano BT, Le TD, Zhu L, Lee YK, Stafford JM
Journal of lipid research, 2016 (57), 1541 - 51
Submitted Externally
27354419
Published

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