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Publication
The docking protein FRS2a is a critical regulator of VEGF receptors signaling.
Authors Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M
Submitted By Submitted Externally on 8/30/2017
Status Published
Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2014
Date Published
Volume : Pages 111 : 5514 - 9
PubMed Reference 24706887
Abstract Vascular endothelial growth factors (VEGFs) signal via their cognate receptor
tyrosine kinases designated VEGFR1-3. We report that the docking protein
fibroblast growth factor receptor substrate 2 (FRS2a) plays a critical role in
cell signaling via these receptors. In vitro FRS2a regulates VEGF-A and
VEGF-C-dependent activation of extracellular signal-regulated receptor kinase
signaling and blood and lymphatic endothelial cells migration and proliferation.
In vivo endothelial-specific deletion of FRS2a results in the profound
impairment of postnatal vascular development and adult angiogenesis,
lymphangiogenesis, and arteriogenesis. We conclude that FRS2a is a previously
unidentified component of VEGF receptors signaling.






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