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Strain
C57BL/6-Lipetm1Gam

Summary Data Summary
Official Name C57BL/6-Lipetm1Gam
Common Name HSL KO
Description The gene was disrupted by insertion of a promoterless
lacZ-neo cassette into exon 1 via homologous recombination.
Absence of gene expression in homozygous mutant animals was
confirmed by Northern and Western blot analyses of adipose
tissue.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Grant MitchellSainte Justine Hospital Research


Genomic Information
GeneAllele 1Allele 2Protocol
LipeknockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.
Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK
American journal of physiology. Endocrinology and metabolism, 2005 (289), E30 - E39
15701680
Published

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