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Strain
C57BL/6J-Itga2tm1Ztr

Summary Data Summary
Official Name C57BL/6J-Itga2tm1Ztr
Common Name C57BL/6J-Itga2-/-
Description Exon 1 was flanked by an upstream floxed neo cassette and a
loxP site inserted into intron 1. Transient transfection of
ES cells with cre recombinase expression plasmids resulted
in the excision of the neo cassette and exon 1. Flow
cytometric analysis of platelets obtained from homozygous
mutant mice showed an absence of surface expression. Western
blot analysis of protein lysates from platelets and mammary
glands confirmed the lack of protien. Neither full-length
nor truncated transcript was detected by RT-PCR analysis of
mammary gland lysates.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6J
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Mary ZutterVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Itga2knockoutknockoutNot Specified


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