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Strain
B6.Cg-Tg(Nes-cre)1Kln/J

Summary Data Summary
Official Name B6.Cg-Tg(Nes-cre)1Kln/J
Common Name Nestin-cre
Description This transgene expresses Cre recombinase with a human growth
hormone polyadenylation signal under the control of a rat
nestin (Nes) promoter and the nervous system-specific
enhancer present in the second intron. This promoter
expresses Cre recombinase in neuronal and glial cell
precursor. Cre recombinase activity is present in nervous
tissue by embryonic day 11. The transgene was localized to
chromosome 12 using FISH with a rat nestin promoter probe
(J:180046).
Development Status Phenotyping complete
Creation Method transgenic
Background C57BL/6J
Phenotype Description This strain is commonly known as nestin-Cre. Nestin promotor
driven Cre recombinase is expressed in the central and
peripheral nervous system, including neuronal and glial cell
precursors. There are reports of Cre recombinase activity in
a few isolated kidney and heart cells. Hemizygous nestin-cre
mice exhibit mild hypopituitarism, growth retardation,
impaired fear response, and a metabolic phenotype. Mice also
show a strong impairment in the acquisition of both
contextual- and cued-fear conditioning.
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 1
Publications 2


Investigators
NameInstitution
Kevin NiswenderVanderbilt University


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedNesCRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARd) in mice leads to increased susceptibility to diet-induced obesity.
Kocalis HE, Turney MK, Printz RL, Laryea GN, Muglia LJ, Davies SS, Stanwood GD, McGuinness OP, Niswender KD
PLoS ONE, 2012 (7), e42981
22916190
Published
Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis.
Kocalis HE, Hagan SL, George L, Turney MK, Siuta MA, Laryea GN, Morris LC, Muglia LJ, Printz RL, Stanwood GD, Niswender KD
Molecular metabolism, 2014 (3), 394 - 407
Submitted Externally
24944899
Published

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