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Strain
B6.129S4-Ppardtm1Rev Tg(Pomc1-cre)1Gsb

Summary Data Summary
Official Name B6.129S4-Ppardtm1Rev Tg(Pomc1-cre)1Gsb
Common Name B6.129S4-Ppardtm1Rev Tg (Pomc1-cre)1Gsb
Description C57BL/6J PPAR delta POMC KO

Ppard knockin: Exon 4, which encodes the amino terminal
portion of the DNA binding domain was left flanked by single
loxP sites after a downstream neo cassette was excised via
the expression of cre recombinase in vitro.

Cre transgene: Cre recombinase cDNA with an IVSpA sequence
was placed within exon 2 of Pomc1, immediately upstream of
the normal translational start site in a BAC clone. Cre was
expressed in the lateral portion of the arcuate nucleus of
mutant brains.
Development Status Phenotyping complete
Creation Method knockout
Background C57BL/6J
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
Kevin NiswenderVanderbilt University


Genomic Information
GeneAllele 1Allele 2Protocol
Ppardknockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedPomc1CRENot Specified


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